Türkiye’deki Yerli Koyun Irklarında BMP-15, BMPR-IB ve GDF-9 Genlerindeki Mutasyonların Belirlenmesi

Gürsel, Feraye Esen; Akiş, Iraz; Durak, H.; Mengi, Ahmet; Öztabak, Kemal

doi:10.9775/kvfd.2011.4256

Cited by 3 publications

(8 citation statements)

References 2 publications

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“…Additionally, the FecX G mutation was identified in Small Tailed Han, Belclare and Cambridge sheep [1,33] . In contrast with results from Gursel et al [20] , our results indicate that the point mutation in FecX G might not serve as a major gene that influences prolificacy in Sakiz sheep. Galway and Inverdale gene polymorphisms were analyzed as likely candidate genes influencing high prolificacy in Sakiz breeds of Greece, but no polymorphism has been identified [27] .…”

Section: Discussioncontrasting

confidence: 99%

“…Our results demonstrate that the FecX I mutation we examined was not present in Sakiz sheep. In addition our results are consistent with reports by Gursel et al [20] .…”

Section: Discussionsupporting

confidence: 94%

“…These results are consistent with reports in Romanov, Finn, Thoka, Woodlands, Olkuska, Lacaune [13] , Sangsari [14] , Akkaraman, Morkaraman, Daglıc, Tuj, Karakas [10] , Awassi, Imroz, Kivircik [20] and Bafra [28] sheep breeds wherein FecB mutant alleles do not segregate in these breeds. In contrast, FecB mutations are reported in several sheep breeds, such as Booroola Merino [7] , Belclare, Cambridge, China Small Tailed Han, Hu [5] , Garole, Javanese [13] , Kendrapada [12] and Romney sheep [17] .…”

Section: Discussionsupporting

confidence: 93%

“…The FecX I mutation was studied in Inverdale, Belclare, Cambridge, Romney, Hanna and Rasa Aragonese, Cambridge, Small Tailed Han, Sakiz [13,16,19] sheep. Recently, Gursel et al [20] report that the Inverdale mutation was identified in Sakiz sheep in Turkey.…”

Section: Introductionmentioning

confidence: 99%

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Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Dinçel¹,

Ardıçlı²,

Soyudal³

et al. 2015

Kafkas Univ Vet Fak Derg

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Fertility traits, such as the ovulation rate and the number of offspring at birth, are genetically regulated by fecundity genes. This study was performed to identify DNA polymorphisms in Booroola (FecB), Galway (FecX G ), Inverdale (FecX I ) and Calpastatin (CAST) genes in Sakiz sheep. A total of 71 ewes were genotyped for gene or allelic polymorphisms in the genes listed above using the PCR-RFLP method. The results obtained from this study indicated that all of the Sakiz ewes sampled were non-carriers for FecB, FecX G or FecX I mutations. However, genotypic frequencies in the CAST gene were 0.59, 0.36 and 0.05 for AA, AB and BB, respectively. A significant deviation from Hardy-Weinberg equilibrium for the CAST gene was not observed in the investigated breed (P>0.05). As a result, more extensive screening is required as tests for newly discovered mutations are developed. Additionally, this study is the first to report a genetic polymorphism in the CAST gene in Sakiz sheep.

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Section: Discussioncontrasting

confidence: 99%

“…Our results demonstrate that the FecX I mutation we examined was not present in Sakiz sheep. In addition our results are consistent with reports by Gursel et al [20] .…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Dinçel¹,

Ardıçlı²,

Soyudal³

et al. 2015

Kafkas Univ Vet Fak Derg

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“…There is substantial need to explore the candidate genes for growth traits in this goat breed. Bone morphogenetic protein-15 (BMP-15), Growth hormone (GH), and Insulin like growth factor-1 (IGF-1) genes are reported as candidate genes for growth and skeletal development in goat [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Beetal Keçisinde FecXG Polimorfizmi ve Filogenetik İlişkisinin İncelenmesi

Basheer¹,

Shareef²,

Islam³

et al. 2018

Kafkas Univ Vet Fak Derg

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The objective of the current study was to detect the incidence of FecX G mutation in 141bp fragment of exon 2 of BMP-15 gene in Beetal goat and to determine its phylogenetic relationship with other goat breeds. In this study 60 Beetal goats were randomly selected and divided equally into two groups on the basis of their body weights. The PCR-RFLP and DNA sequencing techniques were employed to explore polymorphism in exon 2 of BMP-15 gene. Upon digestion with Hinf1, the purified product showed heterozygous carriers with two bands (111bp, and 54bp) in all animals. The analysis of polymorphism for FecX G in Beetal goat indicates that the genetic factor responsible for difference in growth rates is not related to the reported mutated alleles of BMP-15 gene. Therefore, it is suggested that polymorphisms in the other regions of BMP-15 gene should be explored which might be responsible for the difference of growth rates in Beetal goat. Phylogenetic tree of mRNA of BMP-15 gene was constructed and the results revealed Teddy as outgroup. Moreover, among all the breeds used in this analysis Teddy is also phenotypically different from other due to its smaller size and greater prolificacy. However, all the remaining breeds were present in a single large clade, with Black Bengal and Markhoz goat in a further single sub-clade and showing maximum divergence from the common ancestor. The Beetal was next to Black Bengal and Markhoz and along with their common ancestor they were present in a single clade.

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Investigation for Mutation in BMPR-1B (FecB) Fecundity Gene in Awassi Sheep

GEDIK

2023

SJAFS

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Reproduction related traits in sheep such as ovulation rate and litter size are traits of high economic importance but as these traits are only expressed in one sex and in mature animals, thus inclusion of them in selection strategies is limited. Therefore, studying genes associated with reproductive events provides genotypic data, which is more useful in genetic improvement of sheep in a short period of time. Such reproductive traits in sheep are genetically controlled by genes having both additive and major effects. Booroola is the first gene identified in Booroola Merino sheep in Australia has major effects on ewe’s reproduction and has gained much popularity in sheep breeding for its immense economic value. Booroola or Bone Morphogenetic Protein Receptor -1B (BMPR-1B) gene is in chromosome 6 and FecB allele is the result of a single mutation in this gene where one copy of this allele results in a significant increase in ovulation rate thus outcome as increased lambing per parturition. The Awassi sheep is an indigenous breed of Turkey and identifying major genes for fecundity could greatly improve their breeding program. To identify the FecB gene in Awassi sheep, 88 blood samples were taken, and DNA was extracted by salting out method. After PCR amplification and AvaΠ digestion, the samples were analyzed for FecB mutation and all of 88 samples were found not to carry the mutant allele (FecB).

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Türkiye’deki Yerli Koyun Irklarında BMP-15, BMPR-IB ve GDF-9 Genlerindeki Mutasyonların Belirlenmesi

Cited by 3 publications

References 2 publications

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Sakız Irkı Koyunlarda FecB, BMP15 ve CAST Genlerindeki Mutasyonların Analizi

Beetal Keçisinde FecXG Polimorfizmi ve Filogenetik İlişkisinin İncelenmesi

Investigation for Mutation in BMPR-1B (FecB) Fecundity Gene in Awassi Sheep

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