The primary purpose of this study is to determine the correlational and structural relationships between the fear, depression and anxiety levels of nurses working in pandemic outpatient clinics during the period when the new coronavirus epidemic was accepted by all segments of the society and learning to live with the epidemic. Hospital-based cross-sectional study design was used in the study. The research population consisted of the nurse employees of six public hospitals with at least 1500 beds operating in different regions of Istanbul. Using the online questionnaire technique, data were collected from 450 nurses who worked in the COVID-19 pandemic outpatient clinic. IBM SPSS 23 and AMOS package programs were used in the analysis of the data. It was determined that the fear (mean:2.32), depression (mean:2.56), and anxiety (mean:2.32) levels of the nurses working in the pandemic outpatient clinics were partially lower than in the previous periods of the epidemic. Structural equation analysis revealed that the positive relationship between fear, depression and anxiety related to the COVID-19 epidemic had a high and acceptable fit index. In the late period of the COVID-19 epidemic, the fear, depression and anxiety levels of nurses working in pandemic outpatient clinics have partially decreased. There are reciprocal and strong positive relationships between the levels of fear, depression and anxiety caused by COVID-19.