Turkish Primary School Students as Carriers of Group A Beta-Hemolytic Streptococci and Susceptibility of Strains to Penicillin and Erythromycin

Altındiş, Mustafa; Dereköy, Fevzi Sefa; Çeri, Ayhan

doi:10.1179/joc.2001.13.4.444

Cited by 3 publications

(4 citation statements)

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“…32,13,16 Resistance to Erythromycin was found in 5.2% isolates in studies by Dumre et al, in Nepal. 22 The resistance to Erythromycin was 3.8% in Ankara as per the studies of Horu et al 34 In the present study, all the 60 isolates were found to be uniformly susceptible to Penicillin and Vancomycin. Five isolates each were found to be resistant to Erythromycin and Clindamycin (8.3% each).…”

supporting

confidence: 50%

“…Figure III shows past history of symptoms in carriers of GAS. The antibiotic sensitivity pattern of the isolates is indicated in [18][19][20][21][22][23][24][25][26] According to seasonal distribution, maximum number of cases were noted in the months of November (12), December (14) and January (10) contributing to 19.7%, 23% and 16.4% respectively. The samples were not collected during the months of April and May when the children had vacation.…”

Section: Resultsmentioning

confidence: 99%

“…21 Altindis et al, compared the rate of GAS carriage of children studying at two different schools. 22 They found that the rate of carriage in healthy children in an impoverished region was 6%, and that the rate in more affluent, suburban students was 28% in Turkey.…”

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confidence: 99%

“…Diagnostic methods: Culture of a throat swab on a sheep blood agar plate remains the standard for the documentation of the presence of Group A streptococci in the upper respiratory tract and for the confirmation of the clinical diagnosis of acute streptococcal pharyngitis. 22 If done correctly, culture of a single throat swab on a blood agar plate has a sensitivity of 90%-95% for the detection of GAS in the pharynx. 23 Probably, the most widely used test for the differentiation of Group A streptococci from other beta-hemolytic streptococci is the bacitracin disc test.…”

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4. Pharyngeal carriage of Group A streptococci among school children

Mukundan¹,

Vijayakumar²

2017

JIMD

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Abstract:Objectives: The aims of the study were to determine the pharyngeal carriage rate of Group A streptococci among school children at Thrissur, Kerala and to determine the antibiotic sensitivity pattern of the above isolates. Materials and methods: Throat swabs were collected from a total of 260 asymptomatic children(130 each from rural and urban areas) of eighth and ninth standard classes during a period between July 2012 and July 2013. Presumptively identified Group A Streptococci (GAS/Streptococcus pyogenes) were serogrouped by agglutination tests using specific antisera. Antibiotic sensitivity was performed by disc diffusion method following CLSI guidelines. Results: The GAS carriage rate noted in the study was 23.1%. Carriage distribution was found to be independent of age, sex and locality with more number of cases during winter season. All the isolates were found to be sensitive to Penicillin and Vancomycin. Five isolates each were found to be resistant to Erythromycin and Clindamycin respectively. Inducible Clindamycin resistance was demonstrated in three of them. GAS was isolated from the throat swab of one child with past history of joint pains and another child with past history of skin infection-both of them presently had findings of heart disease. Conclusion: When screened and appropriately treated with antibiotics, carriers can be prevented from spreading streptococcal infections in the school environment and the community. Combined efforts by clinicians, community health personnel and clinical microbiologists are required for the early detection and control of streptococcal infections. .

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confidence: 99%

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4. Pharyngeal carriage of Group A streptococci among school children

Mukundan¹,

Vijayakumar²

2017

JIMD

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Distribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region

Rafei

Hawli

Osman

et al. 2020

Journal of Global Antimicrobial Resistance

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Asymptomatic throat carriage rate and antimicrobial resistance pattern of <i>Streptococcus pyogenes</i> in Nepalese school children

Dumre

Sapkota²,

Adhikari³

et al. 1970

Kathmandu Univ. Med. J.

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Background: Streptococcus pyogenes or Group A streptococcus (GAS) causes several suppurative and non suppurative infections. In addition to pharyngitis and skin infections, GAS are also the causative agent of post-streptococcal infection syndromes such as acute rheumatic fever (ARF) and post-streptococcal glumerulonephritis (PSG). GAS frequently colonises in the throat of an asymptomatic person. Pharyngeal carriage rates of GAS among healthy school children vary with geographical location and seasons. Objectives: We carried out this preliminary study to determine the throat carriage rate and antimicrobial resistance trend of Streptococcus pyogenes or Group A streptococcus (GAS) among the Nepalese school children. Materials and methods: Four schools situated at different locations of Kathmandu valley were included in the study. Throat swabs from 350 students of age group 5-15 years were collected, immediately transported to the laboratory and were processed for S. pyogenes following standard microbiological procedures. Antimicrobial susceptibility testing of the isolates was performed by Kirby Bauer disc diffusion method following CLSI guidelines. Results: S. pyogenes was isolated from 10.9% (38/350) of the screened children. The GAS colonisation rate was statistically insignificant (P>0.05) with sex and age sub-groups, although the rate was slightly higher among girls and age sub-group 9-12 years. No significant difference in carrier rate was observed among different schools (P>0.05). All isolates were susceptible to azithromycin. No resistance was detected for penicillin and its derivative antibiotic ampicillin. Highest resistance rate was observed for cotrimoxazole (71.0%) followed by chloramphenicol (7.8%), ciprofl oxacin (5.2%) and erythromycin (5.2%). Conclusion: Antibiotic resistant GAS isolated from asymptomatic Nepalese school children is a public health concern. When screened and appropriately treated with antibiotics, carriers can be prevented from spreading of streptococcal infections in the school environment and the community. Preventing cross infections would ultimately reduce the incidence of life-threatening sequelae which are debilitating and difficult to treat. It is recommended to conduct regular screening and GAS surveillance in schools, and maintain rational use of antibiotics to minimise GAS carriage/infections and resistance. Key words: Streptococcus pyogenes; Antibiotics Resistance; Throat carriage; Children; Nepal. DOI: 10.3126/kumj.v7i4.2760 Kathmandu University Medical Journal (2009) Vol.7, No.4 Issue 28, 392-396

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Turkish Primary School Students as Carriers of Group A Beta-Hemolytic Streptococci and Susceptibility of Strains to Penicillin and Erythromycin

Cited by 3 publications

References 7 publications

4. Pharyngeal carriage of Group A streptococci among school children

4. Pharyngeal carriage of Group A streptococci among school children

Distribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region

Asymptomatic throat carriage rate and antimicrobial resistance pattern of <i>Streptococcus pyogenes</i> in Nepalese school children

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