Turkish Cypriot paternal lineages bear an autochthonous character and closest resemblance to those from neighbouring Near Eastern populations

Gürkan, Cemal; Sevay, Huseyin; Demirdov, Damla Kanliada; Hossoz, Sinem; ÇEKER, Deren; Teralı, Kerem; Erol, Ayla Sevim

doi:10.1080/03014460.2016.1207805

Cited by 13 publications

(23 citation statements)

References 44 publications

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“…The haplogroup assigning procedure in the TCy sample was initially performed ‘blinded’ to the original study’s haplogroup assignments, in order to avoid ascertainment (assessor) bias in haplogroup assignment. Following the haplogroup assignment in the TCy sample, the results were compared to those from the original study[14] and a very high degree of agreement (S3 Table) was observed, with minor differences being due to the slightly different assigning procedures followed. The Y-STR haplotypes and assigned Y-haplogroups (as well as details for the assigning procedure) for GCy and TCy population samples can be found in S1 and S3 Tables, respectively,…”

Section: Methodsmentioning

confidence: 99%

“…For comparison purposes, a publicly available Turkish Cypriot (TCy) population sample (n = 380 Y-STR haplotypes)[14] (YHRD accession number: YA003850) was analyzed (S3 Table). Although these TCy haplotypes were assigned haplogroups in silico in the original study using one of the tools used in the current study (Whit Athey’s Predictor), this procedure was repeated, following the same methodology used in the GCy population sample (described in detail above), with the only difference being that no SNP testing was performed, as the actual samples were not available.…”

Section: Methodsmentioning

confidence: 99%

“…This database includes the aforementioned TCy sample[14], as well as a previously published sample of Greek Cypriots [12]. The TCy haplotypes were at a lower resolution than the GCy haplotypes (17- vs 23-STRs), so the database was restricted to the following 17 markers included in the AmpFlSTR® Yfiler® kit: DYS19, DYS385a/b, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, and Y-GATA-H4.…”

Section: Methodsmentioning

confidence: 99%

“…In main tables and figures only results from our newly typed sample are presented, due to: (i) the lack of clarification regarding confirmation of Cypriot ancestry (i.e. two generations confirmed ancestry, as in the current study sample and the TCy sample)[14] in the previously published GCy sample (recruited primarily from a blood donation biobank); and (ii) potential bias due to decreased genetic diversity resulting from resampling from the same relatively small source possible (i.e. GCy).…”

Section: Methodsmentioning

confidence: 99%

“…Previous population genetic studies have identified that both Greek Cypriots (GCy)[10–13] and Turkish Cypriots (TCy)[14] show genetic affinity with surrounding Southeast European and particularly Near Eastern populations. Despite historical records on the origins of GCy and TCy, the genetic ancestry of the two communities has not as yet been systematically compared.…”

Section: Introductionmentioning

confidence: 99%

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Y-chromosomal analysis of Greek Cypriots reveals a primarily common pre-Ottoman paternal ancestry with Turkish Cypriots

et al. 2017

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Genetics can provide invaluable information on the ancestry of the current inhabitants of Cyprus. A Y-chromosome analysis was performed to (i) determine paternal ancestry among the Greek Cypriot (GCy) community in the context of the Central and Eastern Mediterranean and the Near East; and (ii) identify genetic similarities and differences between Greek Cypriots (GCy) and Turkish Cypriots (TCy). Our haplotype-based analysis has revealed that GCy and TCy patrilineages derive primarily from a single gene pool and show very close genetic affinity (low genetic differentiation) to Calabrian Italian and Lebanese patrilineages. In terms of more recent (past millennium) ancestry, as indicated by Y-haplotype sharing, GCy and TCy share much more haplotypes between them than with any surrounding population (7–8% of total haplotypes shared), while TCy also share around 3% of haplotypes with mainland Turks, and to a lesser extent with North Africans. In terms of Y-haplogroup frequencies, again GCy and TCy show very similar distributions, with the predominant haplogroups in both being J2a-M410, E-M78, and G2-P287. Overall, GCy also have a similar Y-haplogroup distribution to non-Turkic Anatolian and Southwest Caucasian populations, as well as Cretan Greeks. TCy show a slight shift towards Turkish populations, due to the presence of Eastern Eurasian (some of which of possible Ottoman origin) Y-haplogroups. Overall, the Y-chromosome analysis performed, using both Y-STR haplotype and binary Y-haplogroup data puts Cypriot in the middle of a genetic continuum stretching from the Levant to Southeast Europe and reveals that despite some differences in haplotype sharing and haplogroup structure, Greek Cypriots and Turkish Cypriots share primarily a common pre-Ottoman paternal ancestry.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Y-chromosomal analysis of Greek Cypriots reveals a primarily common pre-Ottoman paternal ancestry with Turkish Cypriots

et al. 2017

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Ancestry estimation of three Mediterranean populations based on cranial metrics

Kranioti

García-Donas

Can

et al. 2018

Forensic Science International

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The estimation of ancestry is an essential benchmark for positive identification of heavily decomposed bodies that are recovered in a variety of death and crime scenes. This is especially true when reconstructing the biological profile of the deceased as most methods for sex, age and stature estimation are population-specific. Ancestry estimation methods vary from traditional morphological assessment of cranial features and biometric quantification to computer-aided shape analysis and classification with specialised software. The current paper aims to explore population differences between three neighbouring countries (Greece, Cyprus and Turkey) that have been in constant interaction through conflicts and population movements from the ancient past to the present day, through cranial measurements. The sample consists of 160 dry crania of Greek origin, 137 dry crania of Greek-Cypriot of origin Cyprus and 380 CT scans from Turks individuals. Twelve measurements were taken in both dry and virtual skulls. Data were submitted to principal component analysis and discriminant function analysis. Intra- and inter-observer error as well as the measurement error between virtual and physical measurements were quantified using TEM, rTEM and R. Measurement error was very low in all cases. Classification accuracy for cross-validated data ranged from 74.1 to 97.9%. The highest accuracy was obtained for the Turks sample both in males and females. The results are in accordance with genetic data on the three populations. These results create great confidence in the application of the produced functions in forensic cases requiring ancestry estimation in Cyprus, specifically to unidentified individuals from the 1974 conflict. In addition, these standards can be applied in other forensic situations where ethnicity is an issue but the geographic area of origin is limited to the area encompassing Turkey, Cyprus and Greece.

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The contribution of NOS3 variants to coronary artery disease: A combined genetic epidemiology and computational biochemistry perspective

Teralı

Ergören

2019

International Journal of Biological Macromolecules

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Turkish Cypriot paternal lineages bear an autochthonous character and closest resemblance to those from neighbouring Near Eastern populations

Cited by 13 publications

References 44 publications

Y-chromosomal analysis of Greek Cypriots reveals a primarily common pre-Ottoman paternal ancestry with Turkish Cypriots

Y-chromosomal analysis of Greek Cypriots reveals a primarily common pre-Ottoman paternal ancestry with Turkish Cypriots

Ancestry estimation of three Mediterranean populations based on cranial metrics

The contribution of NOS3 variants to coronary artery disease: A combined genetic epidemiology and computational biochemistry perspective

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