Turkey-Syria Relations

Tür, Özlem

doi:10.4324/9781315549545

Cited by 19 publications

(5 citation statements)

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“…Differentiation of NPCs to neural cultures caused fewer changes in translation within 5 ′ UTRs, and in the opposite direction to what is found from hESCs to NPCs (82 genes: 54 up in the 5′ UTR and 28 down; Figure 2B). Translation of uORFs can positively or negatively affect translation of the downstream ORF (Brar et al, 2012;Hinnebusch et al, 2016). We found that genes that experienced increased 5 ′ UTR ribosomes during differentiation generally had decreased ribosome profiling signal in the main ORF and vice versa ( Figure S2C).…”

Section: Widespread Translation Changes During Neuronal Differentiationmentioning

confidence: 90%

“…Most methods to measure global translation specifically measure the occupancy of assembled 80S ribosomes on mRNA. Translation is frequently regulated at the initiation step (Hinnebusch et al, 2016), and ribosome occupancy correlates with protein levels (Floor and Doudna, 2016;Ingolia et al, 2009). However, regulated translation elongation decouples ribosome occupancy and protein synthesis, because stalled ribosomes are not actively synthesizing protein.…”

Section: Discussionmentioning

confidence: 99%

“…Ribosomes can initiate translation at upstream start codons in mRNA 5′ UTRs (uORFs), which affects translation from the major open reading frame (ORF; (Brar et al, 2012;Hinnebusch et al, 2016). We hypothesized that hESC differentiation into neural precursors would result in a redistribution of ribosomes away from mRNA 5 ′ UTRs, as was observed in mouse embryoid body formation (Ingolia et al, 2011).…”

Section: Widespread Translation Changes During Neuronal Differentiationmentioning

confidence: 98%

“…We next identified features of mRNAs that were associated with differential translation during neuronal differentiation. Even if the coding sequence is identical between two alternatively processed transcripts of a gene, the level of protein output can differ due to changes in the regulatory composition of untranslated regions at the 5′ and 3′ ends (Arribere and Gilbert, 2013;Floor and Doudna, 2016;Hinnebusch et al, 2016;Mayr, 2016;Mayr and Bartel, 2009;Sandberg et al, 2008;Sterne-Weiler et al, 2013). We therefore compared the impact of transcript isoform properties in polysome-low versus polysome-high clusters that might influence translation, such as the density of various regulatory elements in the 3′ UTR or codon usage ( Figure S4A).…”

Section: ′ Untranslated Regions Repress Translation Selectively In Nmentioning

confidence: 99%

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Widespread translational remodeling during human neuronal differentiation

Blair

Hockemeyer

Doudna

et al. 2017

Preprint

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Faithful cellular differentiation requires precise coordination of changes in gene expression. However, the relative contributions of transcriptional and translational regulation during human cellular differentiation are unclear. Here, we induced forebrain neuronal differentiation of human embryonic stem cells (hESCs) and characterized genomewide RNA and translation levels during neurogenesis. We find that thousands of genes change at the translation level across differentiation without a corresponding change in RNA level. Specifically, we identify mTOR complex 1 signaling as a key driver for elevated translation of translation-related genes in hESCs. In contrast, translational repression in active neurons is mediated by transcript 3′ UTRs, through regulatory sequences. Together, our findings identify a functional role for the dramatic 3′ UTR extensions that occur during brain development, and provide insights to interpret genetic variants in post-transcriptional control factors that influence neurodevelopmental disorders and diseases.

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Section: Widespread Translation Changes During Neuronal Differentiationmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Widespread Translation Changes During Neuronal Differentiationmentioning

confidence: 98%

Section: ′ Untranslated Regions Repress Translation Selectively In Nmentioning

confidence: 99%

See 2 more Smart Citations

Widespread translational remodeling during human neuronal differentiation

Blair

Hockemeyer

Doudna

et al. 2017

Preprint

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“…Economic integration aimed to construct new cross--border "liberal" interdependencies that would also permit the export of Turkish business in need of regional markets. 61 The Arab Uprising initially upset Turkey's strategy, which had prioritized economic integration with its Arab neighbourhood regardless of their authoritarian governance. Turkey initially opposed North Atlantic Treaty Organization intervention in Libya where it had close business ties with the regime.…”

Section: Saudi Arabia (And the Gulf Cooperation Council): A New "Holymentioning

confidence: 99%

Globalization, democratization, and the Arab uprising: the international factor in MENA's failed democratization

Hinnebusch

2015

Democratization

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What explains the almost negative impact of international factors on post-Uprising democratization prospects? This article compares the utility of rival "diffusionist" and neo-Gramscian political economy frames to explain this. Three international factors deter democratization. The failure of Western democracy promotion is rooted in the contradiction between the dominance of global finance capital and the norm of democratic equality; in the periphery, neo-liberalism is most compatible with hybrid regimes and, at best, "low intensity democracy." In MENA, neo-liberalism generated a crony capitalism incompatible with democratization; while this also sparked the uprisings, these have failed to address class inequalities. Moreover at the normative level, MENA hosts the most credible counter-hegemonic ideologies; the brief peaking of democratic ideology in the region during the early uprisings soon declined amidst regional discourse wars. Non-democrats-coercive regime remnants and radical charismatic movements-were empowered by the competitive interference of rival powers in Uprising states. The collapse of many Uprising states amidst a struggle for power over the region left an environment uncongenial to democratization.

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Contemporary conflicts, cross‐border military operations, and the declining role of the UN: The case of Turkey and Saudi Arabia

Nyadera

Kisaka

2020

Digest Mid East Studies

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This article examines an emerging trend of cross‐border conflicts between states and non‐state actors. It looks at the narratives fronted by Turkey and Saudi Arabia to justify their operations in northern Syria and Yemen, respectively. The authors argue that the increased inaction and lack of influence by the UN in response to such operations reaffirm states as the core actors in international politics and that national security and interests continue to shape the behavior of actors at the international level. The article concludes that the UN needs to adjust to the new forms of conflicts, actors, and behavior being experienced at the international level if it is to retain its relevance as an anchor of peace and international security.

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Turkey-Syria Relations

Cited by 19 publications

References 0 publications

Widespread translational remodeling during human neuronal differentiation

Widespread translational remodeling during human neuronal differentiation

Globalization, democratization, and the Arab uprising: the international factor in MENA's failed democratization

Contemporary conflicts, cross‐border military operations, and the declining role of the UN: The case of Turkey and Saudi Arabia

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