TurboBeads magnetic nanoparticles functionalized with gold as a promising nano-radiosensitizer for potential breast cancer radiotherapy: In vitro study

Darwesh, Reem; Aboushoushah, Samia; Almarhabi, Sahar; Aldahlawi, Alia; Elbialy, Nihal Saad

doi:10.1016/j.inoche.2020.108348

Cited by 4 publications

(1 citation statement)

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“…A strong focal point of these 2D studies has been the investigation of ways to enhance radiosensitivity of the cells to overcome radiation resistance. One of the commonly studied methods is the use of metallic nanoparticles [ 54 , 55 , 56 ] and magnetic nanoparticles [ 57 , 58 ] to improve the therapeutic efficiency of radiation treatment of cancer cells. Irradiated nanoparticles enhance the dose deposited locally by producing secondary electrons that add to ROS production and DNA damage within the cell [ 56 ].…”

Section: Current Preclinical Tools To Evaluate Effects Of Radiation Therapymentioning

confidence: 99%

3D Breast Tumor Models for Radiobiology Applications

Ravichandran

Clegg

Adams

et al. 2021

Cancers

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Breast cancer is a leading cause of cancer-associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two-dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three-dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre-clinical 3D models offer in improving our understanding of this treatment modality.

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