Tunisian inland water microflora as a source of phycobiliproteins and biological activity with beneficial effects on human health

Abstract

Ten monoclonal microalgal cultures were obtained from several Tunisian inland water bodies, and their dichloromethane and methanolic extracts were screened for antibacterial, antileishmanial, and antioxidant properties, as well as phycobiliprotein production capacity. Cylindrospermopsis raciborskii has been shown to synthesize high levels of phycocyanin and may be an effective alternative source to other sources used for commercial production of phycocyanin. Chroococcus sp. and Leptolyngbya sp1. exhibited the strongest radical scavenging activity against DPPH (IC50 = 212.15 and 263.91 μg ml−1, respectively), indicating their promising potential for use as new effective and non-toxic antioxidants. Furthermore, Dunaliella sp. showed an interesting antileishmanial activity against the pathogens Leishmania infantum and Leishmania major (IC50 = 151 and 284 μg ml−1, respectively), thus representing a good candidate for use against cutaneous and visceral leishmaniasis in Tunisia, a country endemic to these diseases where thousands of new cases are registered every year. These results suggest that the strains of microalgae featured in this work have the potential to serve as natural alternative, safe and sustainable sources of high value-added products that could be used to improve the final biomass value.

Antifungal activity of eukaryotic microalgae in dermatophytes

“…Due to the diversity and richness of bioactive substances, microalgae have become promising in biotechnology, mainly due to their biological activities in the pharmacological area 3 . Several compounds extracted from microalgae revealed potent biological activities, such as antioxidant 4 , anticancer 5 , antibacterial 6 , antiprotozoal 7 , antiviral 8 and antifungal 9 .…”

Potencial antifúngico de extratos da microalga Pyramimonas virginica frente a fungos dermatófitos

“…Compostos fitoquímicos, resultantes do metabolismo primário e secundário, já foram isolados a partir de microalgas, como carotenóides, flavonóides, terpenóides, glicosídeos, esteróis, PUFAs e fenólicos (Barkia et al, 2019;Sathasivam et al, Research, Society and Development, v. 13, n. 3, e5913345297, 2024(CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v13i3.45297 3 2019. Estas substâncias já foram associadas à diversas atividades biológicas, tais como antiviral (Turkmen & Akyurt, 2021), antiprotozoária (Gharbi et al, 2021), antibacteriana (Guleria et al, 2024) e antifúngica (Lage et al, 2023).…”