Tuning the properties of magnesium phosphate-based bone cements: Effect of powder to liquid ratio and aqueous solution concentration

Gelli, Rita; Mati, Laura; Ridi, Francesca

doi:10.1016/j.msec.2018.10.083

Cited by 36 publications

(26 citation statements)

References 48 publications

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“…In fact, samples from A to F show similar values of setting times, likely due to a similar amount of formed struvite. The combined characterization of the set cements by means of XRD, FE-SEM, and thermal analysis allowed us to gain insights into the type of phases present in the cement: it is known from the literature that TMP and DAHP react forming struvite as a binding phase, 42 whereas the nature of citrate inclusion in the cement matrix is not known. In particular, the goal of this investigation was to understand if this ion is included in the inorganic matrix as an unreacted material or if it can react with TMP, thus forming a new binding phase.…”

Section: Discussionmentioning

confidence: 99%

“…Cements. The initial consistency and the handling properties of the pastes were evaluated by observing their appearance immediately after mixing (see Figure 1): when TMP powder (characterization reported elsewhere 42 ) is mixed with DAHP and DAC-based solutions, an easily moldable paste quickly forms. As the citrate content in the formulation increases, pastes appear more uniform and less viscous, displaying improved handling properties.…”

Section: Characterization Of the Pastes And Of The Setmentioning

confidence: 99%

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Unravelling the Effect of Citrate on the Features and Biocompatibility of Magnesium Phosphate-Based Bone Cements

Gelli

Pompo

Graziani

et al. 2020

ACS Biomater. Sci. Eng.

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In the framework of new materials for orthopedic applications, Magnesium Phosphate-based Cements (MPCs) are currently the focus of active research in biomedicine, given their promising features; in this field, the loading of MPCs with active molecules to be released in the proximity of newly forming bone could represent an innovative approach to enhance the in vivo performances of the biomaterial. In this work, we describe the preparation and characterization of MPCs containing citrate, an ion naturally present in bone which presents beneficial effects when released in the proximity of newly forming bone tissue. The cements were characterized in terms of handling properties, setting time, mechanical properties, crystallinity, and microstructure, so as to unravel the effect of citrate concentration on the features of the material. Upon incubation in aqueous media, we demonstrated that citrate could be successfully released from the cements, while contributing to the alkalinization of the surroundings. The cytotoxicity of the materials toward human fibroblasts was also tested, revealing the importance of a fine modulation of released citrate to guarantee the biocompatibility of the material.

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Section: Discussionmentioning

confidence: 99%

Section: Characterization Of the Pastes And Of The Setmentioning

confidence: 99%

Unravelling the Effect of Citrate on the Features and Biocompatibility of Magnesium Phosphate-Based Bone Cements

Gelli

Pompo

Graziani

et al. 2020

ACS Biomater. Sci. Eng.

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“…187 Magnesium phosphate-based cements (MPCs) might replace the wide application of calcium phosphate-based cements (CPCs), due to the synthetical excellent mechanical properties, degradation rate and pronounced bone regeneration capacity. 187,188 Gelli et al 189 proved that the use of 2.0 M and 3.5 M DAHP solution contributes to the formation of compact and hard cements, the compressive strength grows with the powder to liquid ratio and the concentration of DAHP solution increases, while inversely proportional to the total porosity of MPCs. Kanter et al 190 demonstrated that the struvite cements (MgNH 4 PO 4 Á6H 2 O) dissolved completely after 10 months and the degradation rate of cement matches with the new bone formation rate at both unloaded and mechanically load-bearing defect sites.…”

Section: Methods Of Fabricating Mg-based Biomaterialsmentioning

confidence: 99%

“…187,188 Gelli et al. 189 proved that the use of 2.0 M and 3.5 M DAHP solution contributes to the formation of compact and hard cements, the compressive strength grows with the powder to liquid ratio and the concentration of DAHP solution increases, while inversely proportional to the total porosity of MPCs. Kanter et al.…”

Section: Development Of Novel Mg-based Biomaterials For Potential Biomedical Applicationsmentioning

confidence: 99%

Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements

Yang

Dou

et al. 2019

J Biomater Appl

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Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing process. Alloying is an effective method to slow down the corrosion rate. However, currently magnesium alloys used as biomaterials are mostly commercial alloys without considering cytotoxicity from the perspective of biosafety. This article comprehensively reviews the status of various existing and newly developed degradable magnesium-based alloys specially designed for biomedical application. The effects of critical alloying elements, compositions, heat treatment and processing technology on the microstructure, mechanical properties and corrosion resistance of magnesium alloys are discussed in detail. This article covers Mg–Ca based, Mg–Zn based, Mg–Sr based, Mg–RE based and Mg–Cu-based alloy systems. The novel methods of fabricating Mg-based biomaterials and surface treatment on Mg based alloys for potential biomedical applications are summarized.

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“…The compact and hard cements were formed with di-ammonium hydrogen phosphate concentration of 2.0 M and 3.5 M. And the compressive strength of MgP cements increased with the P/L ratio and with the concentration of di-ammonium hydrogen phosphate solution, while the total porosity of MgP cements showed an opposite trend. 105…”

Section: Magnesium Phosphate Cementsmentioning

confidence: 99%

Biodegradable magnesium phosphates in biomedical applications

et al. 2022

J. Mater. Chem. B

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Tuning the properties of magnesium phosphate-based bone cements: Effect of powder to liquid ratio and aqueous solution concentration

Cited by 36 publications

References 48 publications

Unravelling the Effect of Citrate on the Features and Biocompatibility of Magnesium Phosphate-Based Bone Cements

Unravelling the Effect of Citrate on the Features and Biocompatibility of Magnesium Phosphate-Based Bone Cements

Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements

Biodegradable magnesium phosphates in biomedical applications

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