Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

Abstract

<p>The fluorescent properties of atomically precise nanoclusters have been regulated by solvent-induced atomic structure transformation and cationic polymer-induced self-assembly for cell imaging and drug delivery.</p>

Synthesis of metal nanoclusters and regulation of their photoluminescent properties

“…3+ 浓度对银纳米团簇荧光强度的影响 [106] ; (c) Ag + 诱导的 金纳米团簇AIE特性示意图 [107] (网络版彩图) 图 13 (a) GC凝胶诱导的金纳米团簇AIE特性示意图 [109] ; (b) 壳聚糖诱导的金纳米团簇AIE特性示意图 [110] ; (c) PAH诱 导的金纳米团簇AIE特性示意图 [111] ; (d) 高浓度PEI诱导银纳 米团簇发光增强 [112] ; (e) 低浓度下, PEI浓度对银纳米团簇荧 光强度的影响 [113] (网络版彩图)…”

“…Figure 13 (a) Schematic AIE characteristics of gold nanoclusters induced by GC gel [109]; (b) schematic AIE characteristics of gold nanoclusters induced by chitosan [110]; (c) schematic AIE characteristics of gold nanoclusters induced by PAH [111]; (d) enhanced luminescence of silver nanoclusters induced by high concentration PEI [112]; (e) effect of PEI concentration on fluorescence intensity of silver nanoclusters at low PEI concentration [113] (color online).…”

Intrinsic Photoluminescence of Solid-State Gold Nanoclusters: Towards Fluorescence Lifetime Imaging of Tissue-Like Phantoms Under Two-Photon Near-Infrared Excitation

“…They are composed of a few and up to 200 atoms, having a size comparable to the Fermi wavelength, and are protected by an organic molecular ligand enriching them with molecular-like properties such as large Stoke shift and tunable intrinsic photoluminescence (PL) ( Akyüz et al, 2020 ), similar to upconversion nanocrystals ( Wang et al, 2021a ; Wang et al, 2021b ). Owing to the aforementioned characteristics, NCs show potential in various applications like cell and tissue imaging ( Liu et al, 2011 ; Chen et al, 2016 ), biolabeling ( Xu et al, 2020 ), catalysis ( Li and Jin, 2013 ), molecular identification ( Zhang et al, 2018 ), ion detection ( Ding et al, 2014 ; Hada et al, 2021c ), etc. Among the most common metal NCs (gold, silver, copper), gold nanoclusters (AuNCs) present noteworthy advantages in terms of biocompatibility and photostability ( Zuber et al, 2019 ).…”

Intrinsic Photoluminescence of Solid-State Gold Nanoclusters: Towards Fluorescence Lifetime Imaging of Tissue-Like Phantoms Under Two-Photon Near-Infrared Excitation

“…They are composed of a few and up to two hundred atoms which are protected by an organic molecular ligand and have a size comparable to the Fermi wavelength enriching them with molecular-like properties such as large Stoke shift and tunable intrinsic photoluminescence (PL) 1 . Owing to the aforementioned characteristics, NCs show potential in a various application like cell and tissue imaging 2,3 , biolabeling 4 , catalysis 5 , molecular identi cation 6 , ion detection 7 , etc. Among the most common metal NCs (gold, silver, copper), gold nanoclusters (AuNCs) present noteworthy advantages in terms of biocompatibility and photostability 8 .…”