Tuning the photophysics of a bio-active molecular probe ‘3-pyrazolyl-2-pyrazoline’ derivative in different solvents: Dual effect of polarity and hydrogen bonding

5-(4-Ethoxyphenyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

“…For related structures, see: Fun et al (2012); Nonthason et al (2011). For background to and applications of pyrazoline derivatives, see: Amir et al (2008); Gong et al (2011); Husain et al (2008); Manna & Agrawal (2009); Ö zdemir et al 2007; Sarkar et al (2010). For the stability of the temperature controller used in the data collection, see: Cosier & Glazer (1986).…”

“…Data collection: APEX2 (Bruker, 2005); cell refinement: SAINT (Bruker, 2005); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL and PLATON (Spek, 2009). antidepressant and anticonvulsant (Özdemir et al, 2007), antimicrobial (Manna & Agrawal, 2009), antiamoebic (Husain et al, 2008), analgesic and anti-inflammatory (Amir et al, 2008) properties, as well as being used as fluorescent sensors (Gong et al, 2011) and fluorescent probes (Sarkar et al, 2010). The title pyrazoline derivative (I) was synthesized because we want to modify the structure of heteroaryl chalcone derivative in order to enhance its fluorescence property, by cyclization with thiosemicarbazide.…”

Selective fluorescence resonance energy transfer from serum albumins to a bio-active 3-pyrazolyl-2-pyrazoline derivative: A spectroscopic analysis

“…The solvent dependent radiative transitions and relaxation dynamics of pyrazole substituted 2-pyrazoline (PZ) from S 1 and S 2 states have been established in our earlier publication [26] In previous studies from our laboratory, interesting uses of PZ as a sensitive fluorescence probe for exploring the local environments in membrane mimetic organized assemblies were demonstrated [27]. The dual effect of polarity and hydrogen bonding of various solvents was also investigated on our current fluorophore (PYZ) and it yielded interesting results [28]. The interaction between PZ and biological receptors like serum albumins has also been investigated but it produced different results than PYZ [29].…”

Novel Green Three-Constituent Natural Deep Eutectic Solvent Enhances Biomass Extraction from Acanthopanax senticosus and the Extraction Mechanism

“…Three different kinds of solvatochromic dyes, including Reichardt’s dye (RD), p -nitrophenylamine (NA), and N , N -diethyl-4-nitroaniline (DENA) were introduced as probes for measurement of the K–T solvatochromic parameters. According to the reported methods, , certain amounts of RD, NA, and DENA were selectively dissolved into methanol. A 100 μL amount of dye solution was added into a 5 mL centrifuge tube each time.…”