Tuning the mechanical properties of self‐assembled mixed‐peptide tubes

Sedman, Victoria L.; Chen, X.; Allen, Stephanie; Roberts, Clive J.; Korolkov, Vladimir V.; Tendler, Saul J. B.

doi:10.1111/jmi.12005

Cited by 22 publications

(19 citation statements)

References 44 publications

(57 reference statements)

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“…Elevating the level of dinapthylalanine peptide in the peptide mixture decreases the nanostructure's stiffness. 1 A density function theory (DFT) study was used to evaluate the basis for the mechanical rigidity of the nanotubes suggesting that despite the porous nature of the crystal lattice, there is an array of rigid nanotube backbones with interpenetrating ''zipper-like'' aromatic interlocks that result in stiffness and robustness ( Fig. 2c and d).…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…Moreover, self-assembly allows the co-assembly of two or more types of building blocks, resulting in increasingly structurally complex nano-assemblies that may have physical and chemical properties that are distinct from those of the original mono-structures. [1][2][3] Organic nanotechnology is clearly a new front in the field of molecular self-assembly of new structures and composite families at the nano-scale. The organic nanotechnology revolution has many similarities as compared to the effect of polymer chemistry development on material science in the 20th century.…”

Section: Introductionmentioning

confidence: 99%

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The physical properties of supramolecular peptide assemblies: from building block association to technological applications

2014

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Bio-inspired nano-materials can be formed by the ordered assembly of elementary building blocks using recognition modules and structural elements. Among the biological sources, peptides and proteins are of special interest due to their role as major structural elements in all living systems, ranging from bacteria to humans in a continuum of magnitudes, from the nano-scale to the macro-scale. Peptides, as short as dipeptides, contain all the molecular information needed to form well-ordered structures at the nano-scale. Here, in light of the significant advancements in the field of peptide nanostructures in the last few years, we provide an updated overview of this subject. The use of these nanostructures was indeed recently demonstrated in various fields including the design of molecular motors based on nanostructure complexation with a metal-organic framework, the delivery of therapeutic agents, the development of energy storage devices and the fabrication of piezoelectric-based sensors.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The physical properties of supramolecular peptide assemblies: from building block association to technological applications

2014

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“…23 Specifically, through the co-assembly of short peptide building blocks, it was possible to produce complex architectures such as "beads on a string", hydrogels and tubes. 20,[24][25][26] In addition, a synthetic triskelion peptide, which self-assembled into spherical structures was used as a template for the formation of fibrils by diphenylalanine peptide. The peptide-peptide interface results in hybrid structure formation.…”

mentioning

confidence: 99%

Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly

Adler‐Abramovich¹,

Marco²,

Arnon³

et al. 2016

ACS Nano

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Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric, and semiconductive properties. Yet, the control over nanotube length in solution has remained challenging, due to the inherent sequential self-assembly mechanism. Here, in line with polymer chemistry paradigms, we applied a supramolecular polymer coassembly methodology to modulate peptide nanotube elongation. Utilizing this approach, we achieved a narrow, controllable nanotube length distribution by adjusting the molecular ratio of the diphenylalanine assembly unit and its end-capped analogue. Kinetic analysis suggested a slower coassembly organization process as compared to the self-assembly dynamics of each of the building blocks separately. This is consistent with a hierarchal arrangement of the peptide moieties within the coassemblies. Mass spectrometry analysis demonstrated the bimolecular composition of the coassembled nanostructures. Moreover, the peptide nanotubes' length distribution, as determined by electron microscopy, was shown to fit a fragmentation kinetics model. Our results reveal a simple and efficient mechanism for the control of nanotube sizes through the coassembly of peptide entities at various ratios, allowing for the desired end-product formation. This dynamic size control offers tools for molecular engineering at the nanoscale exploiting the advantages of molecular coassembly.

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“…The diphenylalanine (FF) structural motif and its derivatives are among the most widely studied minimal building blocks that allow the formation of ordered polymer-like assemblies at the nano-scale [17][18][19][20] . This class of molecular species exhibits effective self-assembly properties, and has been shown to generate a rich variety of ultrastructures, with functional physical and chemical properties, including piezoelectricity 21,22 , luminescence 23 and robust mechanical characteristics [24][25][26][27][28][29] . Moreover, it is becoming increasingly clear that the ability to control the structures of self-assembled peptides at interfaces has great potential for a multitude of future applications 30 .…”

mentioning

confidence: 99%

Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

et al. 2014

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The self-assembly of molecular building blocks into nano-and micro-scale supramolecular architectures has opened up new frontiers in polymer science. Such supramolecular species not only possess a rich set of dynamic features as a consequence of the non-covalent nature of their core interactions, but also afford unique structural characteristics. Although much is now known about the manner in which such structures adopt their morphologies and size distributions in response to external stimuli, the kinetic and thermodynamic driving forces that lead to their transformation from soluble monomeric species into ordered supramolecular entities have remained elusive. Here we focus on Boc-diphenylalanine, an archetypical example of a peptide with a high propensity towards supramolecular self-organization, and describe the pathway through which it forms a range of nano-assemblies with different structural characteristics. Our results reveal that the nucleation process is multi-step in nature and proceeds by Ostwald's step rule through which coalescence of soluble monomers leads to the formation of nanospheres, which then undergo ripening and structural conversions to form the final supramolecular assemblies. We characterize the structures and thermodynamics of the different phases involved in this process and reveal the intricate nature of the transitions that can occur between discrete structural states of this class of supramolecular polymers.

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Tuning the mechanical properties of self‐assembled mixed‐peptide tubes

Cited by 22 publications

References 44 publications

The physical properties of supramolecular peptide assemblies: from building block association to technological applications

The physical properties of supramolecular peptide assemblies: from building block association to technological applications

Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly

Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

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