Tuning the interactions between chiral plasmonic films and living cells

Abstract

Designing chiral materials to manipulate the biological activities of cells has been an important area not only in chemistry and material science, but also in cell biology and biomedicine. Here, we introduce monolayer plasmonic chiral Au nanoparticle (NP) films modified with l- or d-penicillamine (Pen) to be developed for cell growth, differentiation, and retrieval. The monolayer films display high chiroptical activity, with circular dichroism values of 3.5 mdeg at 550 nm and 26.8 mdeg at 775 nm. The l-Pen-NP films accelerate cell proliferation, whereas the d -Pen-NP films have the opposite effect. Remote irradiation with light is chosen to noninvasively collect the cells. The results demonstrate that left circularly polarized light improves the efficiency of cell detachment up to 91.2% for l-Pen-NP films. These findings will facilitate the development of cell culture in biomedical application and help to understand natural homochirality.

Chirality‐Based Biosensors

“…This important feature was based on the chirality of either chiral ligand‐modified NPs (Au NPs or QDs) or intrinsic chiral nanomaterials that could be used for chiral recognition . The chiral ligand‐modified NPs used for chiral recognition were adapted to introduce enantiomeric bio‐interaction systems for modulating the morphology of cell growth …”

“…C, D) Chiral Au NPs monolayer films for modeling of cell growth, and the corresponding CD and cell morphologies on chiral films. Reproduced with permission . Copyright 2017, the Authors, published by Springer Nature.…”

“…Here, we review the classic fabricated architectures using biomolecules, in which the structural characteristics of these assemblies, and their corresponding chiroptical effects largely affected the detection performance such as sensitivity and types of targets. The selective responses of chiral nanoassemblies to external molecules have allowed their application in chiral configuration switching and as bio‐interacting components or substrates for biomonitoring, and in the development of various chirality‐based biosensors. We and others have developed chirality‐based biosensors for a range of small molecules (antibiotics, toxins, and chemicals), macromolecules (DNA and protein), and biomarkers in living cells (protein and microRNA).…”

Recent Progress in Macromolecule‐Anchored Hybrid Gold Nanomaterials for Biomedical Applications

“…Further design of conjugating AuNPs with amphiphilic polymers could lead to AuNPs@polymeric micelles, which could further increase the stability of AuNPs as well as provide a unique and tailorable platform to encapsulate pharmaceutical molecules for targeted drug or gene delivery or combined photothermal therapy, and even as theranostic species. Incorporating the polymer backbone with film or hydrogel formation ability could provide a 3D support and tunable control on patterning of AuNPs to satisfy the antibacterial application, development for cell growth, smart carrier for sustained or photothermally controllable therapeutical molecule release at the disease site, which opened a new door for pristine AuNPs in biomedical utilizations. Hence, we strongly believe that polymer–AuNP hybrids could be exploited to be practical biomaterials in various fields such as imaging, controlled release, drug delivery, photothermal cancer therapy, etc.…”

Chiral AuCuAu Heterogeneous Nanorods with Tailored Optical Activity

“…The significance of chirality phenomenon has been addressed in different fields, including the evolution of life, [ 1,2 ] enantioselectivity in asymmetrical reactions or biointeractions, [ 3 ] and spin polarization selectivity in chiral nanomaterials for spin chemistry and devices. [ 4,5 ] Nanoparticle fabrication technology have been well developed in recent years that provide rich strategy for chiral construction.…”