Tuning Physical Properties of GelMA Hydrogels through Microarchitecture for Engineering Osteoid Tissue
Ewa Walejewska,
Ferry P. W. Melchels,
Alessia Paradiso
et al.
Abstract:Gelatin methacryloyl (GelMA) hydrogels have gained significant attention due to their biocompatibility and tunable properties. Here, a new approach to engineer GelMAbased matrices to mimic the osteoid matrix is provided. Two crosslinking methods were employed to mimic the tissue stiffness: standard cross-linking (SC) based on visible light exposure (VL) and dual cross-linking (DC) involving physical gelation, followed by VL. It was demonstrated that by reducing the GelMA concentration from 10% (G10) to 5% (G5)… Show more
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