We report the detection of nuclear magnetic resonance (NMR) using an anisotropic magnetoresistive (AMR) sensor. A ''remotedetection'' arrangement was used in which protons in flowing water were prepolarized in the field of a superconducting NMR magnet, adiabatically inverted, and subsequently detected with an AMR sensor situated downstream from the magnet and the adiabatic inverter. AMR sensing is well suited for NMR detection in microfluidic ''lab-on-a-chip'' applications because the sensors are small, typically on the order of 10 m. An estimate of the sensitivity for an optimized system indicates that Ϸ6 ؋ 10 13 protons in a volume of 1,000 m 3 , prepolarized in a 10-kG magnetic field, can be detected with a signal-to-noise ratio of 3 in a 1-Hz bandwidth. This level of sensitivity is competitive with that demonstrated by microcoils in superconducting magnets and with the projected sensitivity of microfabricated atomic magnetometers.anisotropic magnetoresistance ͉ microfluidics ͉ NMR ͉ adiabatic fast passage T he three essential elements of a nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) experimentnuclear spin polarization, encoding, and detection-can be spatially separated; this is referred to as ''remote detection'' of NMR or MRI (1). One important potential advantage of this approach is that encoding and detection can occur in a near-zero magnetic field; however, conventional inductive detection has poor sensitivity at low frequencies, necessitating the use of alternative techniques for detection. Superconducting quantuminterference device (SQUID) magnetometers (2) and alkalivapor atomic magnetometers (3, 4) have been used successfully for this purpose. Magnetoresistance of thin films is a promising technology for sensitive magnetometry in small packages (5), and hybrid sensors involving superconducting pickup loops and magnetoresistive sensors have recently reached sensitivities on the order of 10-100 pG/ ͌ Hz (6, 7), approaching the sensitivities demonstrated by SQUIDs or atomic magnetometers (8). At room temperature, sensitivities on the order of 0.1-1 G/ ͌ Hz have been achieved by using spin valves or magnetic tunnel junctions with an area of Ϸ100 m 2 (9). Here we report the use of anisotropic magnetoresistive (AMR) sensors, operating at room temperature, for a remote-NMR experiment. Such thinfilm magnetoresistive sensors may be particularly attractive for microfluidic applications because they are small and require neither cryogenics nor vapor-cell heating (in contrast to SQUIDs and atomic magnetometers, respectively).The experimental setup is shown in Fig. 1. Tap water, prepolarized by f lowing through a Bruker 17-T magnet, then f lows through an adiabatic inversion region where its polarization is periodically reversed, after which it f lows past an AMR detector. The adiabatic polarization inverter incorporates a set of coils in anti-Helmholtz configuration to supply a gradient of B z along the direction of the water f low. A second set of Helmholtz coils is used to apply a 5.5-...