Tuning of granulopoietic signaling byde novodesigned agonists
Timo Ullrich,
Christoph Pollmann,
Malte Ritter
et al.
Abstract:Enhancing cytokine-based therapies by systematically tuning how an agonist associates its receptor is emerging as a powerful new concept in drug discovery. Here, we report the design and characterization of agonists that tune the granulocyte-colony stimulating factor receptor (G-CSFR) activity, which is central for the proliferation and granulocytic differentiation of hematopoietic stem cells. Using design agonists, we study the impact of varying the receptor-binding affinity and dimerization geometry on recep… Show more
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