Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch

Dehorter, Nathalie; Ciceri, Gabriele; Bartolini, Giorgia; Lim, Lynette; Pino, Isabel del; Marı́n, Oscar

doi:10.1126/science.aab3415

Cited by 146 publications

(161 citation statements)

References 42 publications

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“…A second possibility is that these interneurons are present in the non-human African ape cortex but do not express TH, do so only transiently, or die prior to our ability to detect them. Commensurate with this possibility, the molecular profile of mouse cortical SST-positive interneurons is malleable (36) and sensory stimuli can cause a switch from the production of TH and dopamine to SST in rat hypothalamic interneurons (37). Finally, TH+ interneurons of non-human African apes may have lost their ability to deviate to cortex from the rostral migratory stream.…”

Section: Discussionmentioning

confidence: 99%

Molecular and cellular reorganization of neural circuits in the human lineage

Sousa

Zhu

Raghanti

et al. 2017

Science

201

184

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To better understand the molecular and cellular differences in brain organization between human and non-human primates, we performed transcriptome sequencing of sixteen regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the non-human African ape neocortex. Our integrated analysis of the generated data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels of organization, with relevance for brain function and disease.

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Section: Discussionmentioning

confidence: 99%

Molecular and cellular reorganization of neural circuits in the human lineage

Sousa

Zhu

Raghanti

et al. 2017

Science

201

184

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“…We can now add survival to the list of findings showing that activity is essential for the migration (Polleux et al, 2002), morphological development (De Marco García et al, 2011), positioning (Lodato et al, 2011), and physiological properties (Dehorter et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism

et al. 2018

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Summary We demonstrate that cortical interneurons derived from ventral eminences, including the caudal ganglionic eminence, undergo programmed cell death. Moreover, with the exception of VIP interneurons, this occurs in a manner that is activity-dependent. In addition, we demonstrate that, within interneurons, Calcineurin, a calcium-dependent protein phosphatase, plays a critical role in sequentially linking activity to maturation (E15–P5) and survival (P5–P20). Specifically, embryonic inactivation of Calcineurin results in a failure of interneurons to morphologically mature and prevents them from undergoing apoptosis. By contrast, early postnatal inactivation of Calcineurin increases apoptosis. We conclude that Calcineurin serves a dual role of promoting first the differentiation of interneurons and, subsequently, their survival.

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“…The spatial segregation argues strongly against the ‘cell state’ possibility. Nevertheless, activity-shaped differences in Er81 expression in fast-spiking cortical interneurons have been shown to mark delay-type or non-delayed firing states (Dehorter e t al , 2015). In addition, activity-dependent induction of Npas4 expression has been described for cortical neurons (Lin et al ., 2008), with implications for homeostatic regulation of sensitivity to inhibitory transmitters.…”

Section: Discussionmentioning

confidence: 99%

Bayesian Sparse Regression Analysis Documents the Diversity of Spinal Inhibitory Interneurons

Gabitto

Pakman

Bikoff

et al. 2016

Cell

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SUMMARY Documenting the extent of cellular diversity is a critical step in defining the functional organization of tissues and organs. To infer cell type diversity from partial or incomplete transcription factor expression data we devised a sparse Bayesian framework that is able to handle estimation uncertainty, and can incorporate diverse cellular characteristics to optimize experimental design. Focusing on spinal V1 inhibitory interneurons, for which the spatial expression of 19 transcription factors has been mapped, we infer the existence of approximately 50 candidate V1 neuronal types, many of which localize in compact spatial domains in the ventral spinal cord. We have validated the existence of inferred cell types by direct experimental measurement, establishing this Bayesian framework as an effective platform for cell type characterization in the nervous system and elsewhere.

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Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch

Cited by 146 publications

References 42 publications

Molecular and cellular reorganization of neural circuits in the human lineage

Molecular and cellular reorganization of neural circuits in the human lineage

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism

Bayesian Sparse Regression Analysis Documents the Diversity of Spinal Inhibitory Interneurons

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