Tuning into miRNAs: A comprehensive analysis of their impact on diagnosis, and progression in asthma

Elrebehy, Mahmoud A.; Abulsoud, Ahmed I.; El-Dakroury, Walaa A.; Abdel Mageed, Sherif S.; Elshaer, Shereen Saeid; Fathi, Doaa; Rizk, Nehal I.; Moustafa, Yasser M.; Elballal, Mohammed S.; Mohammed, Osama A.; Abdel-Reheim, Mustafa Ahmed; Zaki, Mohamed Bakr; Mahmoud, Abdulla M.A.; Rashad, Ahmed A.; Sawan, Eman S.; AL-Noshokaty, Tohada M.; Saber, Sameh; Doghish, Ahmed S.

doi:10.1016/j.prp.2024.155147

Pathology - Research and Practice

2024

DOI: 10.1016/j.prp.2024.155147

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Tuning into miRNAs: A comprehensive analysis of their impact on diagnosis, and progression in asthma

Mahmoud A. Elrebehy,

Ahmed I. Abulsoud,

Walaa A. El-Dakroury

et al.

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New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play?

Lin,

Law,

Hettick

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review To describe recent findings of diisocyanate-mediated mechanisms in allergy and toxicology by addressing the role of microRNA (miR) in immune responses that may contribute to the development of occupational asthma (OA). Recent findings Studies of diisocyanate asthma have traditionally focused on the immune and inflammatory patterns associated with diisocyanate exposures; however, recognized knowledge gaps exist regarding the detailed molecular mechanism(s) of pathogenesis. Recent studies demonstrate the critical role endogenous microRNAs play as gene regulators in maintaining homeostasis of the human body, and in the pathophysiology of many diseases including asthma. Given that diisocyanate-OA shares many pathophysiological characteristics with asthma, it is likely that miR-mediated mechanisms are involved in the pathophysiology of diisocyanate-OA. Recent reports have shown that changes in expression of endogenous miRs are associated with exposure to the occupationally relevant diisocyanates, toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). Continued mechanistic study of these relevant miRs may lead to the development of novel biomarkers of occupational exposure and/or provide efficacious targets for therapeutic strategies in diisocyanate asthma. Summary The molecular mechanisms underlying diisocyanate-OA pathophysiology are heterogeneous and complicated. In this review, we highlight recent research into the roles and potential regulation of miRs in diisocyanate-OA.

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New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play?

Lin,

Law,

Hettick

2024

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

show abstract

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Tuning into miRNAs: A comprehensive analysis of their impact on diagnosis, and progression in asthma

Cited by 1 publication

References 85 publications

New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play?

New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play?

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