Tuning inflammation in tuberculosis: the role of decoy receptors

Liberto, Diana Di; Caccamo, Nadia; Meraviglia, Serena; Guggino, Giuliana; Manna, Marco Pio La; Sireci, Guido; Salerno, Alfredo; Dieli, Francesco

doi:10.1016/j.micinf.2009.05.004

Cited by 8 publications

(8 citation statements)

References 50 publications

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“…Although only three of these receptors have been identified in mammals, D6 has been intensely studied due to its capacity to be recognized by multiple chemokines during inflammation (reviewed in Di et al, 2009). In this context, studies challenging D6 deficient mice with complete Freund's adjuvant described an extensive inflammation characterized by leukocyte infiltration with localized areas of severe necrosis (Martinez de la et al, 2005).…”

Section: Chemokines In Mtb Infectionmentioning

confidence: 99%

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Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

Sasindran¹,

Torrelles²

2011

Front. Microbio.

201

186

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Tuberculosis is still a major health problem in the world. Initial interactions between Mycobacterium tuberculosis and the host mark the pathway of infection and the subsequent host inflammatory response. This inflammatory response is tightly regulated by both the host and the bacterium during different stages of infection. As infection progresses, the initial intense pro-inflammatory response observed is regulated by suppressive mediators balancing inflammation. In this environment, M. tuberculosis battles to survive interfering with the host inflammatory response. In this review we discuss the major effector molecules involved in inflammation in relation to the different stages of M. tuberculosis infection.

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Section: Chemokines In Mtb Infectionmentioning

confidence: 99%

“…Tir8 is described to participate in the tight regulation of the immune response by inhibiting TLR/IL-1 NFκB activation (Polentarutti et al, 2003). In vivo studies using Tir8 deficient mice showed that, like D6 deficient mice, Tir8 play a role in damping the immure response against M.tb infection (Di et al, 2009). …”

Section: Chemokines In Mtb Infectionmentioning

confidence: 99%

Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

Sasindran¹,

Torrelles²

2011

Front. Microbio.

201

186

View full text Add to dashboard Cite

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“…Decoy receptors are ‘‘silent scavengers” of CC chemokines and cytokines, which play a key role in damping inflammation and tissue damage [28]. Decoy receptors recognize certain inflammatory cytokines with high affinity and specificity, but are structurally incapable of signaling or presenting the agonist to signaling receptor complexes.…”

Section: Decoy Receptor Role In Humans and Murine Sle-like Modelsmentioning

confidence: 99%

“…At present, the DcR6 receptor, expressed on endothelial cells, hematopoietic stem cells (HSC), megakaryocytes, mast cells, and DC, is the focus of intense investigation in the field of inflammation since it binds many inflammatory CC chemokines (CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL14, CCL22, and weakly CCL17), without triggering any signals in target cells [28]. Interestingly, although previous studies have always focused on the anti-inflammatory role of DcR6 in relationship with its capacity to scavenge circulating proinflammatory CC chemokines, recent studies in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, have suggested that DcR6 functions may be different and can change depending on the setting of the inflammatory conditions.…”

Section: Decoy Receptor Role In Humans and Murine Sle-like Modelsmentioning

confidence: 99%

Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?

Guggino

Giardina

Ciccia

et al. 2012

Clinical and Developmental Immunology

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In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.

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“…The host mounts an effective immune and inflammatory response; it is clearly important to control M. tuberculosis infection in macrophages. However, the response of optimal anti-M. tuberculosis may restrain the inflammatory process, as excessive inflammation may lead to increase tissue damage and contribute to TB active disease development (Di Liberto et al 2009). …”

Section: Please Scroll Down For Articlementioning

confidence: 99%

Gas Chromatography Time-Of-Flight Mass Spectrometry-Based Metabolomic Analysis of Human Macrophages Infected byM. tuberculosis

Cheng

Che

et al. 2013

Analytical Letters

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Tuberculosis is a common infectious disease caused by a bacterium called M. tuberculosis. Invasion of human macrophages is a critical step for establishing a mycobacterial infection. Many protocols, such as M. tuberculosis genomics and proteomics, have been used to discuss the pathogenesis of M. tuberculosis. This work describes a GC/MS metabolomics approach to investigate the metabolome variation of human macrophages infected by different M. tuberculosis strains. The pathogenic mechanism of M. tuberculosis was discussed from the metabolic terminal of macrophages. It was quite remarkable that most of the differential metabolites had the very similar regularity and variation tendency after infection by different virulent strains. The results suggested that M. tuberculosis invaded and infected macrophages largely through three different pathways, including glutathione anabolic metabolism, lipid biosynthesis and metabolism, and carbohydrate biosynthesis and metabolism. These pathways were affected after the invasion of M. tuberculosis, and the immunomodulatory responses of macrophages were activated at the same time. Understanding the mechanisms of macrophages to respond to the invasion of M. tuberculosis from different perspectives will help developing more effective methods to prevent, diagnose, and treat tuberculosis in the future.

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Tuning inflammation in tuberculosis: the role of decoy receptors

Cited by 8 publications

References 50 publications

Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?

Gas Chromatography Time-Of-Flight Mass Spectrometry-Based Metabolomic Analysis of Human Macrophages Infected byM. tuberculosis

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