Tuning bio-aerogel properties for controlling drug delivery. Part 2: Cellulose-pectin composite aerogels

Groult, Sophie; Buwalda, Sytze J.; Budtova, Tatiana

doi:10.1016/j.bioadv.2022.212732

Cited by 19 publications

(15 citation statements)

References 52 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bioaerogels have also found application in food packaging, as a catalyst support and absorption/adsorption material . In the last decade, bioaerogels have attracted increasing interest as biomaterials, thanks to their unique properties. , For example, our group recently prepared pectin and pectin–cellulose aerogels for pH-controlled release of theophylline. − …”

Section: Introductionmentioning

confidence: 99%

Crosslinker-Free Hyaluronic Acid Aerogels

et al. 2022

Self Cite

View full text Add to dashboard Cite

Aerogels based on hyaluronic acid (HA) were prepared without any chemical crosslinking by polymer dissolution, network formation via nonsolvent-induced phase separation, and supercritical CO2 drying. The influence of solution pH, concentration of HA, and type of nonsolvent on network volume shrinkage, aerogel density, morphology, and specific surface area was investigated. A marked dependence of aerogel properties on solution pH was observed: aerogels with the highest specific surface area, 510 m2/g, and the lowest density, 0.057 g/cm3, were obtained when the HA solution was at its isoelectric point (pH 2.5). This work reports the first results ever on neat HA aerogels and constitutes the background for their use as advanced materials for biomedical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Crosslinker-Free Hyaluronic Acid Aerogels

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…3 The obtained theophylline loading efficiencies of starch xerogels and aerogels by far exceed all values reported for bioaerogels and other drugs that are around 15%−30% for starch-and alginate-based aerogels, 2 20%−80% for pectinbased aerogels, 3 and 50%−100% for cellulose-pectin aerogels. 5 Theophylline loading efficiencies and capacities of all dry samples from different starches were analyzed as a function of material density and specific surface area. No trends for the loading efficiency were recorded (Figure S7).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…31,32 The concentrations of theophylline in SGF and in SIF during release were determined with periodical spectrophotometric measurements (UV-1800 spectrophotometer, Shimadzu) at a wavelength of 271 nm using a quartz cuvette with an optical path length of 10 mm, as described in our previous works. 3,5,27 An automated setup consisted of a UV-1800 spectrophotometer combined with Peristaltic sipper 206-23790-53 and Sipper Unit 160C (all from Shimadzu). After each measurement, the probe solution was replaced into the releasing bath.…”

Section: = ×mentioning

confidence: 99%

“…We also estimated the theoretical time needed for the theophylline molecule to reach the center of the alcogel (sample half thickness) using the diffusion approach for a hypothetical case of no interactions between the drug and starch: (5) where L is the half thickness of the starch alcogel disk (around 4−5 mm), and D is the diffusion coefficient of theophylline in the starch alcogel (around 4.92 × 10 −11 m 2 /s) which was roughly estimated as being 10 times lower 28,29 than the theophylline diffusion coefficient in ethanol, the latter calculated using the Stokes−Einstein equation for the radius of theophylline, 0.37 nm, 30 and viscosity of ethanol, 1.20 × 10 −3 Pa•s, at 25 °C.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Starch Alcogels, Aerogels, and Aerogel-like Xerogels: Adsorption and Release of Theophylline

Zou

Budtova

2023

ACS Sustainable Chem. Eng.

Self Cite

View full text Add to dashboard Cite

Starch is one of the most abundant and biodegradable natural polysaccharides; it has been widely used in pharmaceutics in tablets, as a disintegrant, or as a porous carrier. In this work, starches in different formsalcogels, aerogels, and low-vacuum-dried materials (named xerogels)were designed and tested as carriers of theophylline. The influence of the starch amylose/amylopectin ratio, concentration in solution, retrogradation time, and drying method (supercritical CO2 drying for aerogels, low-vacuum drying for xerogels) on materials’ density, specific surface area, and morphology was investigated. The precursors before drying were starch alcogels made by water-to-ethanol exchange in retrograded hydrogels. Starch alcogels were loaded with theophylline via impregnation. Loading capacities and efficiencies of alcogels, aerogels, and xerogels were determined, and release of the drug from xerogels and aerogels was evaluated. Two remarkable phenomena were obtained: (1) The low-vacuum drying method resulted in starch aerogel-like materials; i.e., xerogels with low densities and specific surface areas above 100 m2/g. (2) Starch alcogels adsorbed theophylline from ethanol resulting in loading efficiency as high as 250%. The results obtained show a new pathway in making aerogel-like polysaccharide materials without drying in supercritical conditions for potential use as drug carriers.

show abstract

“…In other cases, biopolymers are selected to substitute non-renewable precursors, i.e., replacing polyol with cellulosic derivatives and plant oils; tannin and lignin polymers often substitute resorcinol and copolymerize with formaldehyde to form resin [ 50 , 51 ]. For example, in pectin (a diverse group of anhydrogalacturonic acid polymers) and starch with a range of methyl esterification of the carboxyl groups (degree of esterification, DE) [ 52 , 53 ], the microstructure and final performance of the gels depend on the chemical structure of the polymer sources (mainly DE) and the gelation mechanism [ 54 ]. Bovine serum albumin and oligo- and polypeptide nanofibrils are generally used to obtain protein aerogels.…”

Section: Biopolymers Employedmentioning

confidence: 99%

Biopolymeric Fibrous Aerogels: The Sustainable Alternative for Water Remediation

et al. 2023

View full text Add to dashboard Cite

The increment in water pollution due to the massive development in the industrial sector is a worldwide concern due to its impact on the environment and human health. Therefore, the development of new and sustainable alternatives for water remediation is needed. In this context, aerogels present high porosity, low density, and a remarkable adsorption capacity, making them candidates for remediation applications demonstrating high efficiency in removing pollutants from the air, soil, and water. Specifically, polymer-based aerogels could be modified in their high surface area to integrate functional groups, decrease their hydrophilicity, or increase their lipophilicity, among other variations, expanding and enhancing their efficiency as adsorbents for the removal of various pollutants in water. The aerogels based on natural polymers such as cellulose, chitosan, or alginate processed by different techniques presented high adsorption capacities, efficacy in oil/water separation and dye removal, and excellent recyclability after several cycles. Although there are different reviews based on aerogels, this work gives an overview of just the natural biopolymers employed to elaborate aerogels as an eco-friendly and renewable alternative. In addition, here we show the synthesis methods and applications in water cleaning from pollutants such as dyes, oil, and pharmaceuticals, providing novel information for the future development of biopolymeric-based aerogel.

show abstract

Tuning bio-aerogel properties for controlling drug delivery. Part 2: Cellulose-pectin composite aerogels

Cited by 19 publications

References 52 publications

Crosslinker-Free Hyaluronic Acid Aerogels

Crosslinker-Free Hyaluronic Acid Aerogels

Starch Alcogels, Aerogels, and Aerogel-like Xerogels: Adsorption and Release of Theophylline

Biopolymeric Fibrous Aerogels: The Sustainable Alternative for Water Remediation

Contact Info

Product

Resources

About