Tuning anion binding properties of Bis(indolyl)methane Receptors: Effect of substitutions on optical responses

Novel Insights in the Hypertension Treatment & Type 2 Diabetics Induced by Angiotensin Receptor Blockers: MD Simulation Studies & Molecular Docking of Some Promising Natural Therapies

“…They have the highest score against the Angiotensin II receptor of any investigated ligand due to two more hydrogen bonds with residues Arg67, Tyr87, and Cys180, among other considerations. Moreover, hydrogen bonds predominated, indicating that the compounds interacted strongly with the receptor. , In particular, this is the first time that the docking interaction between these naturally occurring substances and the Angiotensin II receptor to accomplish the aforementioned biological activity as an antihypertensive has been identified.…”

“…Moreover, hydrogen bonds predominated, indicating that the compounds interacted strongly with the receptor. 42,43 In particular, this is the first time that the docking interaction between these naturally occurring substances and the Angiotensin II receptor to accomplish the aforementioned biological activity as an antihypertensive has been identified.…”

Tuning sensing efficacy of anthraimidazoledione-based charge transfer dyes: nitro group positioning impact

“…14 However, in polar protic solvents like MeOH and EtOH, the absorption spectra were broader with noticeable hypochromism, possibly due to the hydrogen bonding interaction of the benzimidazole –NH protons with solvent molecules. 15 In the same solvent, the absorption maxima of compound 2 ( meta isomer) were found to be blue-shifted (approximately 10 nm) compared to those of 1 and 3 . To further explore the effect of the positions of the nitro functional group on the extent of intramolecular charge transfer, we recorded the FT-IR spectra of compounds ( 1–3 ) in acetonitrile medium (Fig.…”

Small-molecule fluorogenic probes based on indole scaffold

“…Nilanjan dey et al designed three chromophoric bis(indolyl) methane-based probes with different terminal groups for the detection of F − and H 2 PO 4 − ions. 82 Indole and aromatic aldehyde coupled in the presence of in situ -prepared HI to form bisindolylmethane derivatives, and then the bisindolylmethane reacted with DDQ to form the conjugated probe. The compound 39 showed one strong absorption band at 423 nm in non-polar and polar aprotic solvents, whereas red shift bands were observed at 482 nm and 489 nm in protic solvents due to hydrogen bonding between indolyl N and solvent molecules.…”