Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for <i>In Vivo</i> Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy

Yuan, Yong; Cheng, Xiaju; Bao, Tao; Zu, Mian; Yan, Liang; Yin, Wenyan; Ge, Cuicui; Wang, Dongliang; Gu, Zhanjun; Zhao, Yuliang

doi:10.1021/acsnano.5b05825

Cited by 386 publications

(270 citation statements)

References 71 publications

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“…In the past few years, there have been a number of reports studying the toxicity of TMDCs nanomaterials in vitro and in vivo 27, 28, 29, 30, 31. At the in vitro level, it was found that the cytotoxicity of MoS 2 , WS 2 , and WSe 2 nanosheets appeared to be low to different cell lines 15, 18, 32, 33.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

et al. 2016

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With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to carefully study the in vivo biodistribution, excretion, and toxicology profiles of different TMDCs, and hopefully to identify the most promising type of TMDCs with low toxicity and fast excretion for further biomedical applications. Herein, the in vivo behaviors of three representative TMDCs including molybdenum dichalcogenides (MoS2), tungsten dichalcogenides (WS2), and titanium dichalcogenides (TiS2) nanosheets are systematically investigated. Without showing significant in vitro cytotoxicity, all the three types of polyethylene glycol (PEG) functionalized TMDCs show dominate accumulation in reticuloendothelial systems (RES) such as liver and spleen after intravenous injection. In marked contrast to WS2‐PEG and TiS2‐PEG, which show high levels in the organs for months, MoS2‐PEG can be degraded and then excreted almost completely within one month. Further degradation experiments indicate that the distinctive in vivo excretion behaviors of TDMCs can be attributed to their different chemical properties. This work suggests that MoS2, among various TMDCs, may be particularly interesting for further biomedical applications owning to its low toxicity, capability of biodegradation, and rapid excretion.

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Section: Introductionmentioning

confidence: 99%

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

et al. 2016

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“…These modifications increase the solubility of QDs to make QDs unnoticeable by the immune system, increase the QD half-life in the blood stream and target QDs to specific ligands or antigens [12]. Different therapeutic and recognition molecules can be attached to the surfaces of NPs and act synergistically [13–14]. QDs were also chosen for their applicability as resonant energy donors in photodynamic therapy.…”

Section: Introductionmentioning

confidence: 99%

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

Saulīte¹,

Dapkutė²,

Pleiko³

et al. 2017

Beilstein J. Nanotechnol.

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Nanotechnology-based drug design offers new possibilities for the use of nanoparticles in imaging and targeted therapy of tumours. Due to their tumour-homing ability, nano-engineered mesenchymal stem cells (MSCs) could be utilized as vectors to deliver diagnostic and therapeutic nanoparticles into a tumour. In the present study, uptake and functional effects of carboxyl-coated quantum dots QD655 were studied in human skin MSCs. The effect of QD on MSCs was examined using a cell viability assay, Ki67 expression analysis, and tri-lineage differentiation assay. The optimal conditions for QD uptake in MSCs were determined using flow cytometry. The QD uptake route in MSCs was examined via fluorescence imaging using endocytosis inhibitors for the micropinocytosis, phagocytosis, lipid-raft, clathrin- and caveolin-dependent endocytosis pathways. These data showed that QDs were efficiently accumulated in the cytoplasm of MSCs after incubation for 6 h. The main uptake route of QDs in skin MSCs was clathrin-mediated endocytosis. QDs were mainly localized in early endosomes after 6 h as well as in late endosomes and lysosomes after 24 h. QDs in concentrations ranging from 0.5 to 64 nM had no effect on cell viability and proliferation. The expression of MSC markers, CD73 and CD90, and hematopoietic markers, CD34 and CD45, as well as the ability to differentiate into adipocytes, chondrocytes, and osteocytes, were not altered in the presence of QDs. We observed a decrease in the QD signal from labelled MSCs over time that could partly reflect QD excretion. Altogether, these data suggest that QD-labelled MSCs could be used for targeted drug delivery studies.

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“…64 Cu 2+ ) with high labeling yield and stability (Supporting Figure S17); ( ii ) As tungsten (W) processes large X-ray absorption coefficient, WS 2 /WO x -PEG nanodots could offer strong contrast under CT imaging (Supporting Figure S18), and may in the meanwhile be used as a radiosensitizer to enhance radiotherapy of cancer; [12b, 16] ( iii ) The functionalities of WS 2 /WO x nanodots could be further enriched by doping with different types of metal ions ( e.g. Mn 2+ , Gd 3+ ) to enable other modalities of imaging such as magnetic resonance imaging (MRI); [12b] ( iv ) Further optimizing the surface modification of WS 2 /WO x nanodots may be helpful not only to allow active targeting of specific biomolecules or lesions of interest, but also to realize renal clearance of those ultra-small nanodots.…”

Section: Resultsmentioning

confidence: 99%

Facile Preparation of Multifunctional WS₂/WO_xNanodots for Chelator-Free⁸⁹Zr-Labeling and In Vivo PET Imaging

Cheng

Kamkaew

Shen

et al. 2016

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While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator-free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom-up synthesized WS2 nanoflakes, we fabricate a unique type of WS2/WOx nanodots, which could function as inherent hard oxygen donor for stable radio-labeling with Zirconium-89 isotope (89Zr). Upon simply mixing, 89Zr can be anchored on the surface of polyethylene glycol (PEG) modified WS2/WOx (WS2/WOx-PEG) nanodots via a chelator-free method with surprisingly high labeling yield and great stability. A higher degree of oxidation in the WS2/WOx-PEG sample (WS2/WOx (0.4)) produces more electron pairs, which would be beneficial for chelator-free labeling of 89Zr with higher yields, suggesting the importance of surface chemistry and particle composition to the efficiency of chelator-free radiolabeling. Such 89Zr-WS2/WOx (0.4)-PEG nanodots are found to be an excellent PET contrast agent for in vivo imaging of tumors upon intravenous administration, or mapping of draining lymph nodes after local injection.

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Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy

Cited by 386 publications

References 71 publications

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

Facile Preparation of Multifunctional WS₂/WO_xNanodots for Chelator-Free⁸⁹Zr-Labeling and In Vivo PET Imaging

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Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy

Cited by 386 publications

References 71 publications

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS2 (M = Mo, W, Ti) Nanosheets

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS2 (M = Mo, W, Ti) Nanosheets

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

Facile Preparation of Multifunctional WS2/WOxNanodots for Chelator-Free89Zr-Labeling and In Vivo PET Imaging

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In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

Facile Preparation of Multifunctional WS₂/WO_xNanodots for Chelator-Free⁸⁹Zr-Labeling and In Vivo PET Imaging