Tungsten-fibre reinforced composite pin with potential applications in orthopaedic surgery

Morgan, H.G.; Ryder, D.A.; Wheble, Victor H.

doi:10.1007/bf02478051

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…Major PTI, i.e. grade 4-6 Checketts-Otterburn PTI, should be managed by removing the infected pins or wires and performing an adequate debridement of the pin tracts to remove all necrotic debris [18,83]. In cases of osteomyelitic pin tracts with sizeable cavities following debridement, the cavities can either be treated by leaving antibiotic beads in the tracts [14] or by using absorbable calcium-sulphate pellets impregnated with antibiotic to back-fill those tracts [38].…”

Section: Treatment Of Pin Tract Infectionmentioning

confidence: 99%

From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation

Ceroni

Grumetz

Desvachez

et al. 2016

Journal of Children's Orthopaedics

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Pin-tract infection (PTI) is the most commonly expected problem, or even an almost inevitable complication, when using external fixation. Left unteated, PTI will progress unavoidably, lead to mechanical pin loosening, and ultimately cause instability of the external fixator pin–bone construct. Thus, PTI remains a clinical challenge, specifically in cases of limb lengthening or deformity correction. Standardised pin site protocols which encompass an understanding of external fixator biomechanics and meticulous surgical technique during pin and wire insertion, postoperative pin site care and pin removal could limit the incidence of major infections and treatment failures. Here we discuss concepts regarding the epidemiology, physiopathology and microbiology of PTI in paediatric populations, as well as the clinical presentations, diagnosis, classification and treatment of these infections.

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Section: Treatment Of Pin Tract Infectionmentioning

confidence: 99%

From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation

Ceroni

Grumetz

Desvachez

et al. 2016

Journal of Children's Orthopaedics

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“…At this stage, the interpretation of this finding remains speculative. As high portal insulin concentrations have been suggested to be associated with decreased insulin clearance due to receptor saturation (10,11), the represent findings may be seen in the light empagliflozin-induced lowering of insulin secretion. However, not all studies support reduced fractional hepatic insulin extraction with increasing glucose loads (12).…”

Section: Discussionmentioning

confidence: 92%

Effects of a single 10mg dose of empagliflozin on postprandial insulin kinetics in patients with postbariatric hypoglycaemia

Schiavon

Herzig

Hepprich

et al. 2021

Preprint

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IntroductionPostbariatric hypoglycaemia (PBH) is an increasingly recognized late metabolic complication of Roux-en-Y gastric bypass (GB) surgery. PBH typically manifests with a fact occurring post-meal hyperglycaemic peak, followed by a disproportionately exaggerated insulin response leading to low glucose levels. On this basis, we evaluated the effect of a single dose of empagliflozin 10mg vs. placebo on parameters of insulin kinetics.Materials and methodsInsulin secretion, hepatic insulin extraction and total insulin clearance were evaluated after a single of empagliflozin 10mg vs. placebo followed by a standardized liquid mixed meal were evaluated in 11 subjects with confirmed PBH after GB over 3h. Parameters of interest were calculated using established mathematical models. Indices were compared between the groups using the Wilcoxon signed-rank test.ResultsTotal beta-cell responsiveness tends to be lower with empagliflozin vs. placebo (24.83±11.00 vs. 27.15±9.68 [10−9 min-1], p=0.150). Total first-pass hepatic insulin extraction increased after empagliflozin compared to placebo (49.6±14.2 vs. 39.7±12.1 %, p=0.006), while no significant effect of empaglizflozin on basal first-pass hepatic insulin extraction was observed (79.7±7.1 vs. 81.1±6.6 %, p=0.521). Total insulin clearance resulted to be significantly lower after empagliflozin compared to placebo (3.91±1.58 vs. 3.00±1.27 l/min, p=0.002).ConclusionThe present analysis suggests that the hypoglycaemia-attenuating effect of SGLT2-inhibition in patients with PBH is mainly mediated by an increment in insulin clearance, with also a tendency to a reduction in insulin secretion.

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Load Bearing Capacity of Traction Pins: A Biomechanical Study

Saha

1977

Proceedings of the Fifth New England Bioengineering Conference

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Tungsten-fibre reinforced composite pin with potential applications in orthopaedic surgery

Cited by 4 publications

References 2 publications

From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation

From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation

Effects of a single 10mg dose of empagliflozin on postprandial insulin kinetics in patients with postbariatric hypoglycaemia

Load Bearing Capacity of Traction Pins: A Biomechanical Study

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