Tunable pH‐Sensitive Poly(β‐amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery

Abstract

The pH sensitivity of a series of PbAEs synthesized from primary amines and diacrylates is studied. By changing alkyl groups of the amine monomers, the pKb can be tuned across a broad range (from 3.5 to 7.2). Micelles formed from a PEG-PbAE block copolymer retain the pH sensitivity of PbAE and can stably load hydrophobic molecules under neutral pH, while quickly dissociate and release their cargoes at pH ≈ 6.0. When the chemotherapy drug DOX is loaded, the micelles show efficient cell proliferation inhibition to HeLa cells and fast intracellular release. Thus, the primary-amine-based PbAEs are shown to be promising in the construction of intracellular targeting drug delivery systems.

Biodegradable Temperature- and pH Dually-responsive Poly(β-amino ester)

“…At room temperature, PBAEs is soluble when pH below 6.5 and insoluble as pH above 6.5 in water. This value is similar to those reported linear poly(beta-amino ester) [13]. The pH sensitive properties of PBAEs were further investigated with the solution transmittance as a function of solution's pH.…”

Stable loading and delivery of disulfiram with mPEG-PLGA/PCL mixed nanoparticles for tumor therapy

“…43 As shown in Figure 3 Since DSF undergoes quick self-catalyzed hydrolysis in water, we could not describe its release profiles. 44,45 Therefore, in order to evaluate the stability of the NP 4/5/1 , we compared the residual DSF concentrations over time.…”

Bisphosphonate‐functionalized poly(β‐amino ester) network polymers

“…It may also be critical that the in vivo degradability can be customized. One recently developed such family of materials are poly(b-amino ester)s (PBAEs), which have been investigated for gene 12,13 and drug [14][15][16][17][18][19][20][21] delivery, and tissue engineering. [22][23][24][25][26][27] They show pH sensitivity in addition to being biodegradable and highly biocompatible.…”