Tunable permeability and selectivity: Heatable inorganic porous hollow fiber membrane with a thermo-responsive microgel coating

Lohaus, Theresa; Wit, Patrick de; Kather, Michael; Menne, Daniel; Benes, Nieck E.; Pich, Andrij; Weßling, Matthias

doi:10.1016/j.memsci.2017.05.052

Cited by 58 publications

(40 citation statements)

References 31 publications

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“…They are crosslinked, water‐swollen polymer entities that swell or deswell due to different stimuli such as changes in pH, temperature or ionic strength . A recently reported application in the field of membrane science is the generation of thermoresponsive hollow fiber filtration membranes by coating them with microgels . The potential of microgels to influence ion transport in electrochemical deionization processes is relevant as well.…”

Section: Introductionmentioning

confidence: 99%

2D Patterned Ion‐Exchange Membranes Induce Electroconvection

Roghmans

Evdochenko

Stockmeier

et al. 2018

Adv Materials Inter

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Concentration polarization is a diffusion‐limited phenomenon for ion transport in electrodialysis based desalination processes. Once a so‐called limiting current is reached, the resistance of the system rises notably manifested as a plateau region in the current–voltage curves. For long it is hypothesized that altering the surface properties of the membrane can overcome the diffusional transport limitation by the induction of electroconvective vortices mixing the laminar boundary layer. To systematically investigate the influence of geometrical and chemical membrane surface topology on the evolution of electroconvection, circular patterns of polystyrene, poly(2‐vinylpyridine) (P2VP), and P2VP microgels are inkjet printed on cation‐exchange membranes. All types of patterns cause an insignificant increase in membrane resistance but they reduce the plateau lengths indicating the desired accelerated onset of electroconvection. In case of polystyrene (PS) patterns, the drop in plateau length results in a small reduction in transport resistance for overlimiting currents. However, membranes modified with linear P2VP and P2VP microgel patterns do exhibit a significantly decreased resistance in this region at a simultaneous increase of the limiting current density. Direct numerical simulations support the interpretation that the surface charge of the printed patterns influences the direction of the vortices being advantageous during ion transport toward the membrane.

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Section: Introductionmentioning

confidence: 99%

2D Patterned Ion‐Exchange Membranes Induce Electroconvection

Roghmans

Evdochenko

Stockmeier

et al. 2018

Adv Materials Inter

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“…Such copolymer microgels can exhibit more than one VPTT and can be functionalized for two‐step responses . Recent applications of such functionalized microgels include actuating applications such as fiber contraction, membrane modification, surface coating, delivery systems, imaging, as well as targeted protein therapy …”

Section: Introductionmentioning

confidence: 99%

Monitoring Microgel Synthesis by Copolymerization of N‐isopropylacrylamide and N‐vinylcaprolactam via In‐Line Raman Spectroscopy and Indirect Hard Modeling

Meyer-Kirschner

Kather

Ksiazkiewicz

et al. 2018

Macro Reaction Engineering

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Functionalized microgels are typically based on structured copolymers, whose synthesis necessitates knowledge of interactions between different monomer units. This contribution presents in‐line Raman and turbidity monitoring of copolymer microgels based on monomers N‐vinylcaprolactam (VCL) and N‐isopropylacrylamide (NIPAM). During reaction, in‐line Raman spectra are evaluated via multivariate indirect hard modeling (IHM) regression, utilizing pure component models based on parameterized peak functions. To account for variation in Raman baseline intensity, the linear IHM baseline is replaced by a curved baseline, resulting in calibration R² above 0.98 and root‐mean‐squared errors of cross‐validation below 0.12 wt%. Spectra taken in‐line during microgel syntheses reveal NIPAM to react slower than VCL in homopolymerization, but faster than VCL in copolymerization. This effect can be used for synthesis of functional microgels, that is, with tunable volume phase transition temperature. This effect is not visible from turbidity measurements, demonstrating the advantage of in‐line Raman monitoring of chemical components in polymerization processes.

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“…In previous works, it was shown that membrane behavior could be tuned by filtrating thermoresponsive PVCL microgels onto a porous membrane support, allowing control over the flow and membrane resistance. [39,41] This temperature-dependent switching of the microgels results in a shift of the hydraulic resistance that can be shown by pure water permeability experiments. Figure 4 shows pure water resistances through a porous membrane with and without PVCL coating.…”

Section: Temperature-response Of Membranesmentioning

confidence: 88%

Trypsin‐Free Cultivation of 3D Mini‐Tissues in an Adaptive Membrane Bioreactor

et al. 2020

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The production of large scaffold‐free tissues is a key challenge in regenerative medicine. Nowadays, temperature‐responsive polymers allow intact tissue harvesting without needing proteolytic enzymes. This method is limited to tissue culture plastic with limited upscaling capacity and plain process control. Here, a thermoresponsive hollow fiber membrane bioreactor is presented to produce large scaffold‐free tissues. Intact tissues, rich in cell‐to‐cell connections and ECM, are harvested from a poly(N‐vinylcaprolactam) microgel functionalized poly(ether sulfone)/poly(vinylpyrrolidone) hollow fiber membrane by a temperature shift. The harvested 3D tissues adhere in successive cultivation and exhibit high vitality for several days. The facile adsorptive coating waives the need for extensive surface treatment. The research is anticipated to be a starting point for upscaling the production of interconnected tissues enabling new opportunities in regenerative medicine, large‐scale drug screening on physiological relevant tissues, and potentially opening new chances in cell‐based therapies.

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Tunable permeability and selectivity: Heatable inorganic porous hollow fiber membrane with a thermo-responsive microgel coating

Cited by 58 publications

References 31 publications

2D Patterned Ion‐Exchange Membranes Induce Electroconvection

2D Patterned Ion‐Exchange Membranes Induce Electroconvection

Monitoring Microgel Synthesis by Copolymerization of N‐isopropylacrylamide and N‐vinylcaprolactam via In‐Line Raman Spectroscopy and Indirect Hard Modeling

Trypsin‐Free Cultivation of 3D Mini‐Tissues in an Adaptive Membrane Bioreactor

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