Tunable Optofluidic Curvature for Micromanipulation

Abstract

Manipulating micro/nanoparticles on deformed liquid interfaces induced by radiation pressure presents an active, non‐invasive, and contactless method. However, a significant challenge arises due to the relatively small magnitude of the radiation force in normal incidence. Nevertheless, this technique holds immense utility in controlling particle movement at interfaces, with numerous applications in both physical and biological contexts. To overcome this, the peculiar properties of total internal reflection (TIR) in retro‐reflection mode are expoited to create a high amplitude bulge on the water surface, which can migrate radius particles as forcibly as the traditional micro‐post paradigm. The bulge height is measured using an interferometric technique, and the underlying physics are demonstrated using an imitated particle with a capillary charge. By shining two pump lasers, an interface shape is created with increasing complexity, and the relative pump laser intensity is tuned to migrate particles in the desired direction. The method provides a non‐invasive and contactless way to remotely actuate almost all types of micro/nanoparticles at the liquid surface.

Laser-induced microbubble as an in vivo valve for optofluidic manipulation in living Mice's microvessels

“…Optofluidics is a rising technology that combines microfluidics and optics, which are widely used in various fields. 1–3 One of its goals is to manipulate flowing liquids and suspension microparticles in the microscale channels. Microvessels in living animals are a typical microfluidic channel.…”