Tunable multi-responsive nano-gated mesoporous silica nanoparticles as drug carriers

Nechikkattu, Riyasudheen; Kong, Jungwon; Lee, Young-Shin; Moon, Hee-Sung; Bae, Jae‐Ho; Kim, Sun‐Hee; Ha, Chang‐Sik

doi:10.1016/j.colsurfb.2021.112119

Cited by 7 publications

(2 citation statements)

References 48 publications

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“…Recently, core-shell structure composites have been extensively studied in adsorption separation, biomass conversion, electrochemical sensing, drug delivery and waste-water treatment [26][27][28][29][30] due to their superior performance. But in hexane cracking reaction, the influence of core-shell structure catalysts on catalytic properties has not been uncovered so far.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of ZSM‐5@Silicalite‐1 core‐shell composites and their application in hexane catalytic cracking

Zhu,

Yang,

Yan

et al. 2023

ChemistrySelect

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A variety of core‐shell structure catalysts with different shell thicknesses were fabricated by hydrothermal coating. Multiple characterization technologies including XRD, SEM, N2 adsorption‐desorption, NH3‐TPD and IR were employed to explore the physicochemical properties of all the samples, demonstrating that the shell layer was successfully introduced on the exterior of the core. The results of hexane cracking disclosed that with the increase of shell thickness, olefins selectivities increased continuously accompanied by a minor decrease of hexane conversion. Only when controlling the shell thickness to 150 nm could manifest the best performance with light olefins yields of 51.1 %, much higher than those of 23.2 % on the core catalyst. On the other hand, the catalyst lifetime was greatly improved, which presented a decrease of only 2.8 % in hexane conversion, relative to 9.7 % on the core catalyst during the reaction period of 80 h. Above exciting phenomenon was attributed to the growth of protective shell outside the core, which passivated the external acid sites greatly, thus side reactions were inhibited dramatically. It is firmly believed that our work provided a novel reference for the production of light oil cracking catalyst in industry, which will make up for the shortage of olefins considerably.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of ZSM‐5@Silicalite‐1 core‐shell composites and their application in hexane catalytic cracking

Zhu,

Yang,

Yan

et al. 2023

ChemistrySelect

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“…MSNs and other nanomaterials have been extensively used to assemble advanced drug delivery systems for stimuli-responsive release. 16,17 The approach proposed here, based on integrating an enzyme as a control unit in the nanomachine, has several advantages compared to other triggering approaches, mainly associated with the unique properties of these biocatalysts. The enzymatic control allows the design of more complex, highly specific and selective release schemes, in which the chemical entity able to disassemble the encapsulation mechanism is in situ generated upon the recognition of the target substrate.…”

Section: Introductionmentioning

confidence: 99%

An enzyme-controlled mesoporous nanomachine for triple-responsive delivery

et al. 2022

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Mesoporous Silica Nanoparticles: Drug Delivery Vehicles for Antidiabetic Molecules

et al. 2023

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Mesoporous silica nanoparticles (MSNs) are promising nanomaterials that are widely used in biomedical applications like drug delivery, diagnosis, bio-sensing and cell tracking. MSNs have been investigated meticulously in the drug-delivery field due to their unique chemical and pharmacokinetic properties, such as highly ordered mesopores, high surface area and pore volume, tuneable pore size, stability, surface functionalisation, and biocompatibility. MSN-based nanocomposites have been used to deliver therapeutic molecules like insulin, GLP-1, exenatide, DPP-4 inhibitor and plasmid-containing GLP-1 genes for managing diabetes mellitus for the last decade. The functionalisation properties of MSNs make them substantially capable of the co-delivery, controlled delivery and stimuliresponsive delivery of antidiabetic drugs. This review focuses on the delivery of antidiabetic therapeutics with special emphasis on the functionalisation of MSNs and stimuliresponsive delivery.

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Tunable multi-responsive nano-gated mesoporous silica nanoparticles as drug carriers

Cited by 7 publications

References 48 publications

Fabrication and characterization of ZSM‐5@Silicalite‐1 core‐shell composites and their application in hexane catalytic cracking

Fabrication and characterization of ZSM‐5@Silicalite‐1 core‐shell composites and their application in hexane catalytic cracking

An enzyme-controlled mesoporous nanomachine for triple-responsive delivery

Mesoporous Silica Nanoparticles: Drug Delivery Vehicles for Antidiabetic Molecules

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