Tunable liquid microlens actuated by infrared light-responsive hydrogel

Zeng, Xuefeng; Jiang, Hongrui

doi:10.1063/1.2996271

Cited by 95 publications

(75 citation statements)

References 16 publications

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“…23,24 Additionally, combination of hyperthermia with other treatments, such as radiation therapy and/or chemotherapy can further enhance the treatment success. 25 In addition to those based on magnetic nanoparticles, there has been significant work with polymer nanocomposites containing gold nanoparticles 6,9,12 and CNT. 4,7,13 Although there have been several interesting demonstrations of remote heating of polymer nanocomposites, modeling of the remote heating still remains unexplored to the best of the author's knowledge.…”

Section: Introductionmentioning

confidence: 99%

“…1 The incorporation of these nanoparticulates into a polymer matrix can result in several interesting properties including improved mechanical, thermal, or electrical behavior, 2 as well as the capability of remote actuation. 3,4 In the last few years, there have been several studies on the remote heating of polymer nanocomposites for a variety of applications, such as actuators, [5][6][7][8] microfluidic valves, 9,10 drug delivery devices, [11][12][13][14][15] and for hyperthermia cancer treatment. [16][17][18][19] For example, an alternating magnetic field (AMF) has been shown to selectively induce heating and shape transition in magnetic shape memory polymer nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

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Remote actuation of hydrogel nanocomposites: Heating analysis, modeling, and simulations

et al. 2011

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Recently, there has been increasing interest in remote heating of polymer nanocomposites for applications such as actuators, microfluidic valves, drug delivery devices, and hyperthermia treatment of cancer. In this study, magnetic hydrogel nanocomposites of poly(ethylene glycol) (PEG) with varying amounts of iron oxide nanoparticle loadings were synthesized. The nanocomposites were remotely heated using an alternating magnetic field (AMF) at three different AMF amplitudes, and the resultant temperatures were recorded. The rate of the temperature rise and the steady state temperatures were analyzed with a heat transfer model, and a correlation of heat generation per unit mass with the nanoparticle loadings was established for different AMF amplitudes. The temperature rise data of a PEG system with different swelling properties were found to be accurately predicted by the model. Furthermore, the correlations were used to simulate the temperatures of the nanocomposite and the surrounding tissue for potential hyperthermia cancer treatment applications. V V C 2010 American Institute of Chemical Engineers AIChE J, 57: 852-860, 2011 Keywords: biomaterials, biomedical engineering, nanotechnology, heat transfer, composite materials IntroductionNanoparticulates, such as iron oxide nanoparticles, gold nanorods and nanoshells, and carbon nanotubes (CNT) can be remotely heated with the application of specific external stimuli, such as radiofrequency fields or near-infrared light. 1 The incorporation of these nanoparticulates into a polymer matrix can result in several interesting properties including improved mechanical, thermal, or electrical behavior, 2 as well as the capability of remote actuation. 3,4 In the last few years, there have been several studies on the remote heating of polymer nanocomposites for a variety of applications, such as actuators, 5-8 microfluidic valves, 9,10 drug delivery devices, [11][12][13][14][15] and for hyperthermia cancer treatment. [16][17][18][19] For example, an alternating magnetic field (AMF) has been shown to selectively induce heating and shape transition in magnetic shape memory polymer nanocomposites. 5,8 In another study, Hawkins et al. demonstrated that addition of iron oxide nanoparticles to a degradable hydrogel matrix can allow heating upon AMF exposure, which was in turn used to manipulate the rates of degradation and drug release.14 AMF heating has also been explored to trigger the collapse of magnetic nanocomposites of N-isopropylacrylamide (NIPAAm), a temperature responsive hydrogel. This phenomenon has been used to demonstrate accelerated drug release, as well as microfluidic valve applications. 10,11,15 In a recent study, Meenach et al. observed favorable cell viability of magnetic NIPAAm nanocomposites with NIH 3T3 murine fibroblasts and also showed heating on the application of Correspondence concerning this article should be addressed to J. Z. Hilt at hilt@ engr.uky.edu. AMF.18 In all these studies, heating of the nanocomposites was a key factor, and precise control...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Remote actuation of hydrogel nanocomposites: Heating analysis, modeling, and simulations

et al. 2011

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“…For example, soft liquid hydrogel microlenses can be remotely focused with IR light, and this is suggested for applications in endoscopy [160]-in contrast to the earlier-mentioned use of chemically responsive hydrogels which require direct stimuli but combine the functions of sensing and actuation. Koerner provides more information on light-triggered polymeric systems [161].…”

Section: Lightmentioning

confidence: 99%

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

2016

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Shape-changing materials open an entirely new solution space for a wide range of disciplines: from architecture that responds to the environment and medical devices that unpack inside the body, to passive sensors and novel robotic actuators. While synthetic shape-changing materials are still in their infancy, studies of biological morphing materials have revealed key paradigms and features which underlie efficient natural shape-change. Here, we review some of these insights and how they have been, or may be, translated to artificial solutions. We focus on soft matter due to its prevalence in nature, compatibility with users and potential for novel design. Initially, we review examples of natural shape-changing materials-skeletal muscle, tendons and plant tissues-and compare with synthetic examples with similar methods of operation. Stimuli to motion are outlined in general principle, with examples of their use and potential in manufactured systems. Anisotropy is identified as a crucial element in directing shape-change to fulfil designed tasks, and some manufacturing routes to its achievement are highlighted. We conclude with potential directions for future work, including the simultaneous development of materials and manufacturing techniques and the hierarchical combination of effects at multiple length scales.

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“…Light controlled microlenses have the potential to replace current technology that uses mechanical or electrical signals. (Zeng & Jiang, 2008) (Zeng & Jiang, 2008).…”

Section: Microlensesmentioning

confidence: 99%

Smart Microfluidics: The Role of Stimuli- Responsive Polymers in Microfluidic Devices

Argentiere¹,

Gigli²,

Gerges³

et al. 2012

Advances in Microfluidics

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Tunable liquid microlens actuated by infrared light-responsive hydrogel

Cited by 95 publications

References 16 publications

Remote actuation of hydrogel nanocomposites: Heating analysis, modeling, and simulations

Remote actuation of hydrogel nanocomposites: Heating analysis, modeling, and simulations

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

Smart Microfluidics: The Role of Stimuli- Responsive Polymers in Microfluidic Devices

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