Tunable, conductive, self-healing, adhesive and injectable hydrogels for bioelectronics and tissue regeneration applications

Panwar, Vineeta; Babu, Anand; Sharma, Anjana; Thomas, Jijo; Chopra, Vianni; Malik, Pinki; Rajput, Swati; Mittal, Monika; Guha, Rajdeep; Chattopadhyay, Naibedya; Mandal, Dipankar; Ghosh, Deepa

doi:10.1039/d1tb01075a

Cited by 34 publications

(49 citation statements)

References 78 publications

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“…Instead of focusing on these general two-polymer or copolymer structures, [77][78][79] our discussion focuses on identifying more complex/unique compositional examples. For instance, Panwar et al [51] have synthesized a carboxymethyl chitosan (CMCh) /carboxymethyl cellulose/PDA (Ch-CMC-PDA) hydrogel by combining CMCh and CMC-D-PDA based on physical and covalent interactions, as shown in Figure 5c. The preformation of CMC-D-PDA proceeds by two steps: introduction of aldehyde groups by CMC oxidation and polymerization of dopamine.…”

Section: Pure Hydrogelsmentioning

confidence: 99%

“…Therefore, researchers have recently focused on developing hydrogels-and their resulting H-TENGs-with the self-healing functionality. [49,51,61,89] To achieve self-healing, most studies have introduced additional dynamic functional groups and/or bonds into hydrogels and triboelectric materials.…”

Section: Self-healingmentioning

confidence: 99%

“…Owing to the unique merits of biocompatibility, biodegradability, and environmental friendliness, hydrogels are often used in biomedical and implantable applications. [139][140][141] The advent of flexible TENGs makes it possible to be applied in similar applications, such as in vivo heartbeat monitoring, [142] drug delivery, [143,144] tissue regeneration, [51] and muscle stimulation. [145] Therefore, a few researchers have also considered H-TENGs into biomedical and implantable applications.…”

Section: Biomedical/implantable Electronicsmentioning

confidence: 99%

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Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Luo

Cuthbert

et al. 2022

Advanced Science

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Flexible triboelectric nanogenerators (TENGs) have attracted increasing interest since their advent in 2012. In comparison with other flexible electrodes, hydrogels possess transparency, stretchability, biocompatibility, and tunable ionic conductivity, which together provide great potential as current collectors in TENGs for wearable applications. The development of hydrogel-based TENGs (H-TENGs) is currently a burgeoning field but research efforts have lagged behind those of other common flexible TENGs. In order to spur research and development of this important area, a comprehensive review that summarizes recent advances and challenges of H-TENGs will be very useful to researchers and engineers in this emerging field. Herein, the advantages and types of hydrogels as soft ionic conductors in TENGs are presented, followed by detailed descriptions of the advanced functions, enhanced output performance, as well as flexible and wearable applications of H-TENGs. Finally, the challenges and prospects of H-TENGs are discussed.

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Section: Pure Hydrogelsmentioning

confidence: 99%

Section: Self-healingmentioning

confidence: 99%

Section: Biomedical/implantable Electronicsmentioning

confidence: 99%

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Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Luo

Cuthbert

et al. 2022

Advanced Science

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Section: Characterization Of Hydrogel Scaffolds and Mps-incorporated Scaffoldsmentioning

confidence: 99%

“…After 15 min of healing, an ambiguous boundary at the healed interface was exhibited by the assembly material, which could maintain the integrity of the healing interface despite subjected to external tensile strength. As a widely used hydrogel material, diverse benefit for a scaffold could be brought by the stable self-healing effect (e.g., injectability, flexible delivery, and adaptability) [36][37][38]. The pore sizes of CMC-OCS, KGN-incorporated CMC-OCS (CMC-OCS@KGN), PLGA MPs@KGN-embedded CMC-OCS (CMC-OCS@MPs@KGN) were 33.03 ± 1.19 µm, 32.71 ± 1.20 µm, and 24.80 ± 1.33 µm, respectively (Figure 4A).…”

Section: Characterization Of Hydrogel Scaffolds and Mps-incorporated Scaffoldsmentioning

confidence: 99%

Fabrication of Injectable Chitosan-Chondroitin Sulfate Hydrogel Embedding Kartogenin-Loaded Microspheres as an Ultrasound-Triggered Drug Delivery System for Cartilage Tissue Engineering

et al. 2021

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Ultrasound-responsive microspheres (MPs) derived from natural polysaccharides and injectable hydrogels have been widely investigated as a biocompatible, biodegradable, and controllable drug delivery system and cell scaffolds for tissue engineering. In this study, kartogenin (KGN) loaded poly (lactide-co-glycolic acid) (PLGA) MPs (MPs@KGN) were fabricated by premix membrane emulsification (PME) method which were sonicated by an ultrasound transducer. Furthermore, carboxymethyl chitosan-oxidized chondroitin sulfate (CMC-OCS) hydrogel were prepared via the Schiff’ base reaction-embedded MPs to produce a CMC-OCS/MPs scaffold. In the current work, morphology, mechanical property, porosity determination, swelling property, in vitro degradation, KGN release from scaffolds, cytotoxicity, and cell bioactivity were investigated. The results showed that MPs presented an obvious collapse after ultrasound treatment. The embedded PLGA MPs could enhance the compressive elastic modulus of soft CMC-OCS hydrogel. The cumulative release KGN from MPs exhibited a slow rate which would display an appropriate collapse after ultrasound, allowing KGN to maintain a continuous concentration for at least 28 days. Moreover, the composite CMC-OCS@MPs scaffolds exhibited faster gelation, lower swelling ratio, and lower in vitro degradation. CCK-8 and LIVE/DEAD staining showed these scaffolds did not influence rabbit bone marrow mesenchymal stem cells (rBMMSCs) proliferation. Then these scaffolds were cultured with rBMMSCs for 2 weeks, and the immunofluorescent staining of collagen II (COL-2) showed that CMC-OCS hydrogel embedded with MPs@KGN (CMC-OCS@MPs@KGN) with ultrasound had the ability to increase the COL-2 synthesis. Overall, due to the improved mechanical property and the ability of sustained KGN release, this injectable hydrogel with ultrasound-responsive property is a promising system for cartilage tissue engineering.

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Bioinspiration as Tools for the Design of Innovative Materials and Systems Bioinspired Piezoelectric Materials

Bera

2023

Bioinspired and Green Synthesis of Nanostructures

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Tunable, conductive, self-healing, adhesive and injectable hydrogels for bioelectronics and tissue regeneration applications

Abstract: Conductive hydrogels are attracting considerable interest in view of their potential in a wide range of applications that include healthcare and electronics. Such hydrogels are generally incorporated with conductive materials/polymers....

Cited by 34 publications

References 78 publications

Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Hydrogels as Soft Ionic Conductors in Flexible and Wearable Triboelectric Nanogenerators

Fabrication of Injectable Chitosan-Chondroitin Sulfate Hydrogel Embedding Kartogenin-Loaded Microspheres as an Ultrasound-Triggered Drug Delivery System for Cartilage Tissue Engineering

Bioinspiration as Tools for the Design of Innovative Materials and Systems Bioinspired Piezoelectric Materials

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