Tunable Antibacterial Coatings That Support Mammalian Cell Growth

Vasilev, Krasimir; Sah, Vasu R.; Anselme, Karine; Ndi, Chi P.; Mateescu, Mihaela; Dollmann, Björn Christian; Martinek, Petr; Ys, Hardi; Ploux, Lydie; Griesser, Hans J.

doi:10.1021/nl903274q

Cited by 150 publications

(129 citation statements)

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“…The study of plasma polymer coatings that could potentially be used in biomedical devices is an area of increasing research interest [1][2][3][4][5]. One of the most common classes of thin film treatments employed in biomaterial devices is that of 'low-fouling' or 'stealth' coatings [6].…”

Section: Introductionmentioning

confidence: 99%

An X-ray and neutron reflectometry study of ‘PEG-like’ plasma polymer films

Menzies

Nelson

Shen

et al. 2011

J. R. Soc. Interface.

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Plasma-enhanced chemical vapour-deposited films of di(ethylene glycol) dimethyl ether were analysed by a combination of X-ray photoelectron spectroscopy, atomic force microscopy, quartz crystal microbalance with dissipation monitoring (QCM-D), X-ray and neutron reflectometry (NR). The combination of these techniques enabled a systematic study of the impact of plasma deposition conditions upon resulting film chemistry (empirical formula), mass densities, structure and water solvation, which has been correlated with the films' efficacy against protein fouling. All films were shown to contain substantially less hydrogen than the original monomer and absorb a vast amount of water, which correlated with their mass density profiles. A proportion of the plasma polymer hydrogen atoms were shown to be exchangeable, while QCM-D measurements were inaccurate in detecting associated water in lower power films that contained loosely bound material. The higher protein resistance of the films deposited at a low load power was attributed to its greater chemical and structural similarity to that of poly(ethylene glycol) graft surfaces. These studies demonstrate the utility of using X-ray and NR analysis techniques in furthering the understanding of the chemistry of these films and their interaction with water and proteins.

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Section: Introductionmentioning

confidence: 99%

An X-ray and neutron reflectometry study of ‘PEG-like’ plasma polymer films

Menzies

Nelson

Shen

et al. 2011

J. R. Soc. Interface.

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“…Plasma polymers are easy to prepare by a well established technology of plasma polymerization. It has a long history of exploitation in a variety of applications, because it is non-toxic, transparent, with a very low surface tension, very good adhesion to any substrate, flexible, and it neither dissolves nor swells in a cell culture medium, insoluble in cold and hot solvents [4,5,6]. From the other hand nanodiamonds are of interest due to the combination of unique properties inherent to diamond and the specific surface structure of particles facilitating its functionalization [1].…”

Section: Introductionmentioning

confidence: 99%

Optical characterization of composite layers prepared by plasma polymerization

Radeva

Hikov

Mitev

et al. 2016

J. Phys.: Conf. Ser.

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Abstract. Thin composite layers from polymer/nanoparticles (Ag-nanoparticles and detonation nanodiamonds) were prepared by plasma polymerization process on the base of hexamethyldisiloxane. The variation of the layer composition was achieved by changing the type of nanoparticles. The optical measurement techniques used were UV-VIS-NIR ellipsometry (SE), Fourier-transformed infrared spectroscopy (FTIR) and Raman spectroscopy. The values of the refractive index determined are in the range 1.30 to 1.42. All samples are transparent with transmission between 85-95% and very smooth. The change in Raman and FTIR spectra of the composites verify the expected bonding between polymer and diamond nanoparticles due to the penetration of the fillers in the polymer matrix. The comparison of the spectra of the corresponding NH3 plasma treated composites revealed that the composite surface becomes more hydrophilic. The obtained results indicate that preparation of layers with desired compositions is possible at a precise control of the detonation nanodiamond materials.

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“…Numerous siloxan-based materials, including polymerized hexamethyldisiloxane (PPHMDS) are developed. PPHMDS was easy to prepare by a well established technology of plasma polymerization (Vasilev et al, 2010. PPHMDS has a long history of exploitation in a variety of applications, because it is non-toxic, transparent, with a very low surface tension, flexible, and it neither dissolves nor swells in a cell culture medium (Min-Hsien, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…The Si-DND samples, obtained by silinaztion are produced in order to prevent formation of DNDs aggregates (Baidakova, Vul', 2007). The incorporation of silver ions in the polymer, lead to production of samples that are highly efficient against bacterial colonization and allows the adhesion and spreading of mammalian cells (Vasilev K et al, 2010, Agarwal et al, 2009. It is found that the adhesion and proliferation of different types of cells on biomaterials depend on many surface characteristics, such as surface charge, wettability (hydrophobicity/hydrophilicity), chemistry, microstructure, roughness, and mechanical properties (Min-Hsien, 2009).…”

Section: Introductionmentioning

confidence: 99%