“…Final diagnosis, of course, remains histopathologic [13], but most authors agree that a pre-operative biopsy of the tumor is not indicated because it can be uninformative and the risk of bleeding, infection and dissemination of malignant cells into the peritoneal cavity or seeding of the biopsy tract is high [7,11]. Complete surgical excision of the epithelial lining with clear resection margins remains the cornerstone option for surgical management of tumors in the retro-rectal space [7,11,13], even if asymptomatic, but treatment may be very challenging when cystic lesions are associated with a fistula or abscess and especially when adjacent structures are involved (sacrum, rectum, blood vessels and nerves) or when the disease is not correctly diagnosed at presentation [7,9]. Furthermore, the risks of recurrence, hemorrhage, chronic infection and malignant degeneration to adenocarcinoma or squamous carcinoma always exists [13].…”