Tumours of the foot and ankle

Khan, Zahid; Hussain, Shakir; Carter, Simon R.

doi:10.1016/j.foot.2015.06.001

Cited by 22 publications

(24 citation statements)

References 17 publications

(24 reference statements)

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“…[9][10][11] In our cohort, the age of diagnosis of malignant bone tumours of the foot peaked in the second and eighth decades of life. This was also found in a review by Khan et al 5 Furthermore, our findings that Ewing's sarcomas commonly present in the second decade of life whereas chondrosarcomas and osteosarcomas usually present between the fourth and sixth decades are supported by those of Bos et al 4 This age of presentation of osteosarcomas of the foot is contrary to the usual age of presentation in the rest of the appendicular skeleton (second and third decades of life). 12 We cannot explain this observation although Choong et al reported similar findings.…”

Section: Discussionsupporting

confidence: 84%

“…Amputation is particularly appropriate for Ewing's sarcoma and osteosarcoma as these tumours are less amenable to limb sparing surgery because of poor tumour compartmentalisation in the foot and difficulty in achieving adequate resection margins. 2,5,13 In our experience, amputation was an appropriate management option for patients with accidental excision. Seven of the eight patients who were referred with initial accidental excision subsequently underwent amputation.…”

Section: Discussionmentioning

confidence: 85%

“…Delays in diagnosis of malignant bony foot tumours may worsen the prognosis and late presentation potentially modifies treatment strategies towards amputation rather than limb salvage. 4,5 There have been few reports of large series documenting malignant foot tumours in the literature so their incidence and clinical outcomes remain poorly established. Most studies published so far have focused on soft tissue sarcomas of the foot rather than osseous malignancies.…”

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confidence: 99%

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Malignant bone tumours of the foot

Yang

Evans

Bali

et al. 2017

annals

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Introduction Malignant osseous foot tumours are uncommon. Their oncological outcomes have been poorly documented in the literature so far. The aim of this study was to establish the incidence and to evaluate the oncological outcomes of such patients. Methods Our large orthopaedic oncology database was used to review 70 malignant osseous foot tumour patients. Results The age at diagnosis of malignant osseous foot tumours demonstrated a bimodal distribution peaking in the second and eighth decades of life. Overall, 55 primary malignant bone tumours of the foot (79%) were identified. The median duration from onset of symptoms to diagnosis was 52 weeks (interquartile range [IQR]: 17-104). Eight primary tumours (15%) underwent an accidental excision (ie intralesional excision of a malignant bone tumour where some of the tumour has been left behind, also known as a 'whoops procedure') prior to referral to our unit. Forty-six patients (84%) underwent surgery overall and thirteen of these developed recurrence or metastases. Seven of eight patients with a previous accidental excision underwent amputation. Fifteen osseous metastatic foot lesions were identified. The median length of foot symptoms to diagnosis was 24 weeks (IQR: 20-36 weeks). The median time to death following diagnosis of osseous foot metastases was 20.1 months (IQR: 11.3-27.8 months). Conclusions A high index of suspicion and awareness of clinical features of malignant osseous foot tumours are both essential to avoid diagnostic delays. Amputation is associated with a respectable outcome for patients who have undergone previous accidental excisions.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 85%

mentioning

confidence: 99%

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Malignant bone tumours of the foot

Yang

Evans

Bali

et al. 2017

annals

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“…Metastasis to the foot and ankle accounts for less than 1% of all metastatic disease . The most common primary pathologies that metastasize to the foot are lung, gastrointestinal, and genitourinary tumors.…”

Section: Malignant Lesionsmentioning

confidence: 99%

Cystic bone tumors of the foot and ankle

Reda

2018

Journal of Surgical Oncology

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Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. This review discusses the most common cystic tumors of the foot and ankle including their radiographic features and principles of management.

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“…этот аспект влияет на объем резецированного участка и степень радикальности операции по удалению пораженного сегмента. Индивидуально опреде-ляется химиотерапевтическое сопровождение в постоперационном периоде [25][26][27][28][29].…”

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RECONSTRUCTION OF BONE DEFECTS AFTER TUMOR RESECTION BY AUTOAND ALLOGRAFTS (review of literature)

Anastasieva

Садовой

Воропаева

et al. 2017

Traumatology and Orthopedics of Russia

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The problem of replacement of large bone defects resulting from segmental bone resections in patients with bone tumors is still actual in modern orthopedics. Segmental defects cause the main difficulty especially in cases of disturbance of normal biomechanics while the “gold standard” of reconstruction with bone autograft is not always possible. The reason is that the defect can be so extensive that would make it impossible to harvest necessary autobone stock. Therefore, allografts based on demineralized bone with optimal properties for osteoregeneration are used as an alternative for autograft. For certain composite materials it is possible to program the properties of future graft by changing its compound. Literature analysis revealed that the effectiveness of the allograft in combination with additional components is comparable to autograft effectiveness. Mesenchymal stem cells of both bone marrow and adipose tissue can be used as an additional component to improve osteoregeneration. It is noteworthy that the analyzed studies did not reveal the influence of stem cells on the tumor recurrence. Nevertheless, the authors support the need of further researches in this area to confirm gained results. Some authors still prefer traditional methods of bone traction despite obtaining own satisfactory results of defects reconstruction with allografts. Such opinion is based on proven effectiveness of the method, structural stability of construction during treatment period and ability to adjust the process of bone regeneration at any stage. The authors goal was to analyze publications over the recent 5 years with the results of experiments and clinical studies on the replacement of large bone defects after bone tumor resection with autoand allografts. Based on the literature analysis the authors propose a general algorithm for graft selection in replacement of large bone defects after segmental bone resections.

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Tumours of the foot and ankle

Cited by 22 publications

References 17 publications

Malignant bone tumours of the foot

Malignant bone tumours of the foot

Cystic bone tumors of the foot and ankle

RECONSTRUCTION OF BONE DEFECTS AFTER TUMOR RESECTION BY AUTOAND ALLOGRAFTS (review of literature)

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