Tumours in Mice Induced by Exposure to Sodium Arsenate in Drinking Water

Ng, J. C.; Seawright, A. A.; Qı, Lei; Garnett, C. M.; Chiswell, B.; Moore, Michael R.

doi:10.1016/b978-008043648-7/50025-x

Cited by 22 publications

(31 citation statements)

References 13 publications

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“…Sodium arsenite was also proved to a carcinogen via the transplacental pathway [10,11]. In this current study we aimed to confirm the study by Ng et al [8] and further evaluate the carcinogenic effect of inorganic arsenic by including a lower and wider range of sodium arsenate concentrations. The water arsenic concentrations are similar to those reported to have caused arsenicosis in As-endemic areas [12].…”

Section: Introductionsupporting

confidence: 63%

“…Although Dimethyl arsenic acid (DMA,) a major metabolite of inorganic arsenic, had been shown to cause bladder cancers in rats [14], inorganic arsenic alone has not been proved to be a carcinogen in any of the known animal models until recently [8]. The carcinogenic effect of arsenic has since been shown to be able to cross the placenta and subsequently induce tumours in the off-spring of pregnant dams exposed to relatively high concentrations of arsenic [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…A group of 105 control mice was given demineralised water containing <0.1 µg As/L. Female mice were used in our previous inorganic arsenic carcinogenicity study [8]. The stock solution of sodium arsenate was prepared and kept in the refrigerator for one month.…”

Section: Methodsmentioning

confidence: 99%

“…The first inorganic arsenic carcinogenicity study with chronic, low-dose exposure was done by Ng et al [8] in C57BL/6J mice exposed to 500 µg As/L sodium arsenate in drinking water for 2 years. The authors reported increased incidence of tumours in various organs of treated mice but not in the control group.…”

Section: Introductionmentioning

confidence: 99%

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Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (As^v) in drinking water for 2 years

Krishnamohan¹,

Seawright²,

Ng³

2010

WIT Transactions on Ecology and the Environment

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Arsenic is a ubiquitous element in the environment and has been classified as a human carcinogen primarily based on epidemiological evidence. It has been estimated there are over 100 million people globally being exposed to elevated arsenic from both natural and anthropogenic sources. Surprisingly, positive carcinogenicity animal studies were lacking until recent years. We aim to validate inorganic arsenate carcinogenic effect in C57Bl/6J mice, and establish the dose-response relationship using environmental concentrations of arsenic similar to those found in typical endemic-areas. Mice were given 0, 100, 250 or 500 µg As/L in the form of sodium arsenate in drinking water ad libitum over 2 years. Tumours occurred after about 18 months of arsenic exposure otherwise the animals appeared to be normal in their appearance and behaviour. Incidences of all types of tumours and non-tumourous lesions in the treated groups were higher than those observed in the control group. The induction of tumours was in a dose-response manner for some tumour types. Enlargement of the mesenteric lymph node due to hyperplasia or neoplasia of lymphoid elements was commonly observed. Apart from abdominal cavity lymph nodes, tumours were frequently observed in the liver, spleen and intestinal wall, and to a lesser extent in the lung with various other tissues also occasionally affected. Of the non-tumourous lesions, haemorrhagic ovarian cysts occurred more frequently in the treated groups than in the control group. Our results suggest that the C57Bl/6J mouse model can be a useful adjunct for further mechanistic studies of arsenic carcinogenesis. This bioassay data may also be considered for the risk evaluation of chronic exposure to inorganic arsenic.

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Section: Introductionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (As^v) in drinking water for 2 years

Krishnamohan¹,

Seawright²,

Ng³

2010

WIT Transactions on Ecology and the Environment

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“…Although arsenic is a known human carcinogen (19), little evidence has been found for its carcinogenicity in animal models (20). However, Ng et al (21) recently reported that tumors were observed in C57Bl/6J and metallothionein knock-out transgenic mice given sodium arsenate (500 µg As/L ad libitum) in drinking water for up to 26 months. Malignant tumors were also produced in Nude mice inoculated with a rat liver epithelial cell line (TRL 1215) after continuous in vitro exposure to sodium arsenite (0.125, 0.250, and 0.500 µM) for 18 weeks (22).…”

Section: Discussionmentioning

confidence: 99%

A Biologically Based Model of Growth and Senescence of Syrian Hamster Embryo (SHE) Cells after Exposure to Arsenic

Liao¹,

Gustafson²,

Fox³

et al. 2001

Environmental Health Perspectives

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Arsenic and its inorganic compounds (with the exception of arsine) [MAK Value Documentation, 2005]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe MAK Value Documentations , 21. Lieferung, Ausgabe 2005 Der Artikel enthält folgende Kapitel: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Absorption, distribution, elimination Metabolism Effects in Man Single exposures Repeated exposures Local effects on skin and mucous membranes Allergenic effects Reproductive and developmental toxicity Genotoxicity Carcinogenicity Animal experiments and in vitro Studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Allergenic effects Reproductive and developmental toxicity Genotoxicity Carcinogenicity Manifesto (MAK value/classification)

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Tumours in Mice Induced by Exposure to Sodium Arsenate in Drinking Water

Cited by 22 publications

References 13 publications

Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (As^v) in drinking water for 2 years

Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (As^v) in drinking water for 2 years

A Biologically Based Model of Growth and Senescence of Syrian Hamster Embryo (SHE) Cells after Exposure to Arsenic

Arsenic and its inorganic compounds (with the exception of arsine) [MAK Value Documentation, 2005]

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Tumours in Mice Induced by Exposure to Sodium Arsenate in Drinking Water

Cited by 22 publications

References 13 publications

Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (Asv) in drinking water for 2 years

Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (Asv) in drinking water for 2 years

A Biologically Based Model of Growth and Senescence of Syrian Hamster Embryo (SHE) Cells after Exposure to Arsenic

Arsenic and its inorganic compounds (with the exception of arsine) [MAK Value Documentation, 2005]

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Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (As^v) in drinking water for 2 years

Carcinogenesis in female C57Bl/6J mice chronically exposed to sodium arsenate (As^v) in drinking water for 2 years