Tumour T-lymphocyte subset infiltration and tumour recurrence following curative resection for colorectal cancer

Ali, A.; McMillan, Donald C.; Matalka, II; McNicol, A. M.; McArdle, C. S.

doi:10.1016/j.ejso.2003.11.018

Cited by 32 publications

(21 citation statements)

References 13 publications

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“…There are a number of possible explanations. Firstly, that an elevated C-reactive protein identifies those patients with an impaired T-lymphocytic response, as poor infiltration of GI tumours appears to be associated with poor outcome (Schumacher et al, 2001;Ali et al, 2004) and an elevated C-reactive protein concentration has recently been shown to be inversely associated with T-lymphocyte subset infiltration (Canna et al, 2005). Indeed, in the present study, an elevated C-reactive protein concentration was associated with greater proportion of patients having lymphocytopenia.…”

Section: Discussionmentioning

confidence: 46%

An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer

et al. 2006

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There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor outcome in patients undergoing resection for a variety of tumours. The aim of the present study was to examine the relationship between clinicopathological status, preoperative C-reactive protein concentration and cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer. One hundred and twenty patients attending the upper gastrointestinal surgical unit in the Royal Infirmary, Glasgow, who were selected for potentially curative surgery, were included in the study. Laboratory measurements of haemoglobin, white cell, lymphocyte and platelet counts, albumin and C-reactive protein were carried out at the time of diagnosis. All patients underwent en-bloc resection with lymphadenectomy and survived at least 30 days following surgery. On multivariate analysis, only the positive to total lymph node ratio (hazard ratio (HR) 2.02, 95% confidence interval (CI) 1.44 -2.84, Po0.001) and preoperative C-reactive protein concentration (HR 3.53, 95% CI 1.88 -6.64, Po0.001) were independent predictors of cancer-specific survival. The patient group with no evidence of a preoperative systemic inflammatory response (C-reactive protein p10 mg l À1 ) had a median survival of 79 months compared with 19 months in the elevated systemic inflammatory response group (Po0.001). The results of the present study indicate that in patients selected to undergo potentially curative resection for gastro-oesophageal cancer, the presence of an elevated preoperative C-reactive protein concentration is an independent predictor of poor cancer-specific survival.

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Section: Discussionmentioning

confidence: 46%

An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer

et al. 2006

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“…An abundant TIL count appears to be linked to earlier Dukes' stage, decreased local recurrence rate following curative surgery and improved overall and disease-free survival time both in non-metastatic and metastatic patients undergoing hepatic resection [10,[68][69][70][71][72][73] . Galon et al [13] evaluated by gene expression profiling and immunohistochemistry, the type, density and location (whether at the invasive margin or the tumor centre) of TILs in a large number of cases.…”

Section: T-lymphocytesmentioning

confidence: 99%

Invasive front of colorectal cancer: Dynamic interface ofpro-/anti-tumor factors

Zlobec¹,

Lugli²

2009

WJG

107

101

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“…More recently, the ability to identify lymphocyte subsets has led to renewed interest in the relationship between the tumour inflammatory infiltrate and outcome. Indeed, increased infiltration of the tumour by CD8 þ and CD4 þ T-lymphocytes has been shown to be associated with increased survival in patients with colorectal cancer (Naito et al, 1998;Ali et al, 2004). In contrast, the presence of an increased infiltration by CD4 þ or CD8 þ T-lymphocytes has been associated with decreased survival in patients with renal cancer (Nakano et al, 2001, Bromwich et al, 2003.…”

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confidence: 99%

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

et al. 2004

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The relationship between tumour stage, T-lymphocyte subset infiltration and survival was examined in patients with prostate cancer (n ¼ 80). On multivariate analysis PSA (HR 2.47, 95% CI 1.27 -4.83, P ¼ 0.008) and CD4 þ T-lymphocyte count (HR 2.29, 95% CI 1.25 -4.22, P ¼ 0.008) had independent significance. Increased CD4 þ T-lymphocyte infiltration within the tumour was stage independent and associated with poor outcome in patients with prostate cancer.

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Tumour T-lymphocyte subset infiltration and tumour recurrence following curative resection for colorectal cancer

Cited by 32 publications

References 13 publications

An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer

An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer

Invasive front of colorectal cancer: Dynamic interface ofpro-/anti-tumor factors

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

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