Abstract:Neural stem cells (NSCs) divide asymmetrically to balance their self-renewal and differentiation. The imbalance can lead to NSC overgrowth and tumour formation. The function of Parafibromin, a conserved tumour suppressor, in the nervous system is not established. Here, we demonstrate that Drosophila Parafibromin/Hyrax (Hyx) inhibits NSC overgrowth by governing the cell polarity. Hyx is essential for the apicobasal polarity by localizing both apical and basal proteins asymmetrically in NSCs. hyx loss results in… Show more
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