Tumour suppressor ABCA8 inhibits malignant progression of colorectal cancer via Wnt/β-catenin pathway

Yang, Kun; Li, Xiaolu; Jiang, Zhongxiang; Li, Junfeng; Deng, Qianxi; He, Jin; Chen, Jun; Li, Xiaoqing; Xu, Shuman; Jiang, Zheng

doi:10.1016/j.dld.2023.10.026

Cited by 2 publications

(1 citation statement)

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“…One key avenue for progress lies in the refinement and expansion of molecular profiling techniques. 235,236 As high-throughput sequencing technologies continue to evolve, the ability to comprehensively analyze the genomic landscape of colorectal cancer tumors becomes more sophisticated. This evolving molecular characterization, encompassing genetic, epigenetic, and proteomic data, will contribute to a more nuanced understanding of the disease, allowing for the identification of novel targets and the development of tailored therapeutic strategies.…”

Section: Future Progression and Challengesmentioning

confidence: 99%

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Section: Future Progression and Challengesmentioning

confidence: 99%