Tumour‐suppressive <i>microRNA‐24‐1</i> inhibits cancer cell proliferation through targeting <i>FOXM1</i> in bladder cancer

Inoguchi, Satoru; Seki, Naohiko; Chiyomaru, Takeshi; Ishihara, Takeshi; Matsushita, Ryo; Mataki, Hiroko; Iwamoto, Toshihiko; Tatarano, Shuichi; Yoshino, Hirofumi; Goto, Yusuke; Nishikawa, Rika; Nakagawa, Masayuki; Enokida, Hideki

doi:10.1016/j.febslet.2014.06.058

Cited by 49 publications

(51 citation statements)

References 37 publications

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“…FOXM1 is a dynamic cancer-associated biomarker involved in the regulation of various biological processes, including cell cycle progression, differentiation, metastasis, invasion and angiogenesis (14)(15)(16)(17)(18). In a previous study, the present authors demonstrated that FOXM1 was overexpressed in cervical cancer tissues, and its nuclear expression was observed to be correlated with the pathological grade of the tumor (19).…”

Section: Introductionmentioning

confidence: 60%

“…In a previous study, the present authors demonstrated that FOXM1 was overexpressed in cervical cancer tissues, and its nuclear expression was observed to be correlated with the pathological grade of the tumor (19). Furthermore, FOXM1 may be involved in the regulation of cancer invasion and metastasis by regulating the expression and activity of matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor (VEGF) (17). Chan et al (20) and He et al (21) also indicated that FOXM1 is important in the tumorigenesis and development of cervical cancer.…”

Section: Introductionmentioning

confidence: 71%

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Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

et al. 2016

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Abstract. Forkhead box M1 (FOXM1) and hedgehog (Hh) signaling pathway are implicated in the formation and development of human tumors, including cervical cancer. Previous studies have indicated that FOXM1 may be a downstream target gene of the Hh signaling pathway, but their association in cervical cancer is largely unknown. In the present study, the expression of FOXM1 and Hh signaling molecules was evaluated by immunohistochemical analysis in a tissue microarray that contained 70 cervical cancer tissues and 10 normal cervical tissues. In addition, the association of these molecules with clinicopathological parameters, and the association between FOXM1 and various molecules involved in the Hh signaling pathway was investigated. The results indicated that FOXM1 and Hh signaling molecules were overexpressed in cervical cancer tissues. The protein expression levels of FOXM1, glioma-associated oncogene 1 (GLI1) and smoothened (SMO) correlated with the clinical stage of the tumors, while the protein expression levels of Sonic Hh (SHh), patched 1 (PTCH1) and GLI1 correlated with the pathological grade of the tumors. The expression levels of GLI1 were lower in tissues without lymph node metastasis than in tissues with lymph node metastasis. In addition, FOXM1 expression correlated with GLI1, SHh and PTCH1 expression in cancer tissues. These findings confirmed the participation of FOXM1 and the Hh signaling pathway in cervical cancer. Furthermore, the finding that FOXM1 may be a downstream target gene of the Hh signaling pathway in cervical cancer provides a potential novel diagnostic and therapeutic target for cervical cancer.

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Section: Introductionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 71%

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

et al. 2016

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“…Zhang et al reported that downregulation of FOXM1 suppressed PLK1-regulated cell cycle progression in renal cancer cells (33). Additionally, Inoguchi et al found that microRNA-24-1 inhibited bladder cancer cell proliferation by targeting FOXM1 (34). Therefore, we inferred that TSN inhibited SGC-7901 cell proliferation and migration via the downregulation of FOXM1.…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1

Wang

et al. 2017

Oncology Reports

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Tanshinone IIA (TSN) exhibits a variety of anticancer effects. However, whether it inhibits gastric cancer (GC) cell proliferation and migration and the mechanism remain unclear. In the present study, different concentrations of TSN were co-incubated with SGC-7901 cells. The pcDNA-FOXM1 or FOXM1-siRNA plasmid was transfected into cells before treatment with 5 µg/l TSN. The proliferation and migration abilities of the SGC-7901 cells were tested by MTT and wound healing assays. Western blotting was used to investigate the expression levels of P21, Ki-67, PCNA, MMP-2, MMP-9 and FOXM1. We found that compared with the control, the proliferation and migration abilities of the SGC-7901 cells were decreased after incubation with different concentrations of TSN in a dose-dependent manner (p<0.01). Moreover, the expression levels of Ki-67, PCAN, MMP-2, MMP-9 and FOXM1 were decreased, and P21 was increased in the TSN-treated SGC-7901 cells (p<0.01). In addition, downregulation of FOXM1 by FOXM1-siRNA had the same effect as TSN on SGC-7901 cells, and overexpression of FOXM1 partly abrogated TSN-mediated inhibition of SGC-7901 cell proliferation and migration. These results suggested that TSN inhibits SGC-7901 cell proliferation and migration by downregulation of FOXM1.

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“…Using the prediction of the miRNA-binding analysis website (http://bioinfo.life.hust.edu.cn/miRNASNP2/index.php), we found that rs2839698 polymorphism in H19 3′ UTR may result in the loss of hsa-miR-24-1-5p and hsa-miR-24-2-5p function. MiR-24 acts as a tumour suppressor and is low-expressed in various types of cancers, including colorectal, prostate and bladder cancer [22–24]. Thus, it is biologically conceivable that the loss of miR-24 function owing to a SNP rs2839698 in the 3′ UTR of H19 may give rise to overexpression of H19 and thereby promote proliferation, migration and invasion of some cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls

Chu

Yuan

et al. 2016

Oncotarget

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H19 refers to a long non-coding RNA (lncRNA) that functions as an oncogenic molecule in different cancer cells. Genetic variants of H19 may affect the activity of certain regulatory factors, which subsequently regulate the aberrant expression of H19. This feedback loop might be one of the underlying mechanisms influencing tumour susceptibility and prognosis. Although there have been several recent studies that examined possible links between polymorphisms in H19 and cancer risk, the results have been inconclusive. Thus, we performed a meta-analysis to estimate the associations between H19 polymorphisms (rs2107425, rs2839698 and rs217727) and cancer risk. Ten studies comprising 13,392 cases and 18,893 controls were included in the study. Overall, the variant T allele of rs2107425 correlated with a significantly decreased risk of developing cancer (dominant model: OR = 0.86; 95% CI = 0.76–0.98). In addition, a marginally significant association between the rs2839698 and cancer risk was observed (dominant model: OR = 1.09; 95% CI = 0.99–1.20). After stratification for ethnicity, it became apparent that Asians with the variant A allele of rs2839698 exhibited a significantly higher risk of developing cancer (dominant model: OR = 1.11; 95% CI = 1.01–1.23). Interestingly, the rs2839698 variant was also significant associated with an increased risk of cancers of the digestive system (dominant model: OR = 1.23; 95% CI = 1.08–1.41). These findings provided evidence that H19 rs2107425 may modify general cancer susceptibility, while rs2839698 may modify cancer susceptibility based on ethnicity and type. Further experimental studies to evaluate the limits of this hypothesis are warranted, and future functional studies are required to clarify the possible mechanisms.

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Tumour‐suppressive microRNA‐24‐1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer

Cited by 49 publications

References 37 publications

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1

Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls

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