Tumour Resistance of Mice Infected With Salmonella Enteritidis 11rx

Ashley, Michael P.; Hardy, David

doi:10.1038/icb.1973.76

Cited by 6 publications

(14 citation statements)

References 2 publications

(3 reference statements)

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“…immunised mice has been shown to be due to a rapid removal of tumour cells from the peritoneal cavit}^ beginning within the first few hours after challenge (Ashley and Hardy, 1973). The present finding, that within a day after challenge of IIRX carrier mice with '^^I-labelled EAT cells most of the ^^4 was excreted, demonstrate.s that the tumour cells are killed and not merely resited.…”

Section: Discussionsupporting

confidence: 61%

“…During the IIRX carrier state the peritoneal eavity contains macrophages with increased bactericidal properties (Rowley et al, 1968) and cells capable of killing EAT cells in vitro (Ashley and Hardy, 1973), although it is not k-nown what role these play in tumour resistance. It is, however, clear that after IIRX immunisation the mice possess a mechanism for rapid tumour cell killing and that, when this capacity has declined, it can be recalled by injection of IIRX antigen.…”

Section: Discussionmentioning

confidence: 99%

“…passa^je in miee is described in a previous paper (Ashley and Hardy, 1973). The challenge dose of tumour cells used for ail experiments was 10" cells injected i.p., equivalent to IO" LD50 (Hardy and Kotlarski, 1971).…”

Section: Ehrlich Ascites Tumour (Eat)mentioning

confidence: 99%

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RECALL OF TUMOUR RESISTANCE IN LONG‐TERM SALMONELLA ENTERITIDIS 11RX IMMUNISED MICE

Ashley¹,

Kotlarski²,

Hardy³

1974

Aust J Exp Biol Med

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Summary Resistance to Ehrlich ascites tumour growth in the peritoneal cavity of mice has been induced by prior immunisation with live Salmonella enteritidis 11RX. A greater and longer lasting anti‐tumour effect was elicited after immunisation by the intraperitoneal (i.p.) route than by the intravenous (i.v.) route. Resistance to tumour could be recalled after either i.p. or i.v. immunisation by i.p. injection of various 11RX antigen preparations, including a preparation which was not protective in normal mice. Resistance was determined by following survival of mice after challenge with tumour cells and by monitoring the death of 131I‐iododeoxyuridine‐labelled tumour cells in vivo. Recall of tumour resistance was attributed to the rapid induction of an in vivo tumour killing mechanism.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

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RECALL OF TUMOUR RESISTANCE IN LONG‐TERM SALMONELLA ENTERITIDIS 11RX IMMUNISED MICE

Ashley¹,

Kotlarski²,

Hardy³

1974

Aust J Exp Biol Med

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“…Similar anti-tumour activity has been shown to be stimulated in the peritoneal exudate cells of mice following infection with bacteria (Ashley and Hardy, 1973) and parasites (Hibbs, Lambert and Remington, 1972;Keller, 1973Keller, , 1974 and following immunization with unrelated antigens (Evans and Alex-ander, 1 972a). We have also reported that administration of C. parvum inhibits tumour growth in vivo, not only in intact mice but also in T cell deficient mice prepared by thymectomy, whole body irradiation and transplantation of isogeneic bone marrow (Woodruff, Dunbar and Ghaffar, 1973).…”

mentioning

confidence: 66%

Further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with Corynebacterium parvum

Ghaffar¹,

Cullen²,

Woodruff³

1975

Br J Cancer

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Administration of C. parvum to both intact and thymectomized mice resulted in the appearance in the peritoneal exudate of cells which inhibited tumour growth in vitro. This effect was mediated by intact, viable adherent cells, which it seems reasonable to categorize as macrophages, and was contingent on contact between the effector and target cells. No co-operation was observed between lymph node cells from C. parvum treated mice and peritoneal exudate cells from normal mice. Images Fig. 3

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“…Tumour resistance of 11 RX-infected mice is associated with the generation of PEC which are tumouricidal in vitro {Ashley and Hardy, 1973). This assay was used to detect the anti-tumour effects of the different bacteria and bacterial preparations in these studies.…”

Section: Generation Of Tumouricidal Pec In Mice Wilh a Primary Bactermentioning

confidence: 99%

FACTORS AFFECTING THE ABILITY OF VARIOUS STRAINS OF ENTEROBACTERIACEAE TO INDUCE TUMOUR RESISTANCE IN MICE

Vingelis

Ashman

Kotlarski

1980

Aust J Exp Biol Med

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Summary. Primary infection of mice with Salmonella enterilidis 1IRX (! lRX)eonfers resistance to challenge with 10* LD50 doses of Ehrlich Ascites tumour (EAT). A lipopolysaccharide-free protein extraet of IIRX is capable of eliciting delayed type hypersensitivity (DTH) reactions in these miee and of "recalling" tumour resistance in long-term 11 RX immunised miee, which no longer exhibit any resistance to tumour challenge.In the present study, we have examined the ability of five other strains of Enlerobacleriaceae to induce similar efTects. Primary i.p. injection of 5. chesier. S. tuton or S. lyphimurium G30 into mice resulted in persisting infeetions and the induction of peritoneal exudate cells (PEC) which were tumourieidal in \iiro. DTH reactions could also be elicited in these animals with protein extracts ofthe homologous or the 1 IRX strain of salmonella. S.fhedcnan and E. coti K12, which did not persist in mice, did not elieit tumouricidal PEC and did not sensitize mice for DTH reaetions. However, protein extracts from all the five strains eould elieit tumouricidal PEC and DTH reactions in long-term 11 RX-immunised mice (but not in normal mice).The results imply that a wide range oi Enlerobacteriaceae may possess antigen(s) whieh can be involved in tumour resistance, provided that these antigen(s) are presented in such a way that a cellular immune response develops.

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Tumour Resistance of Mice Infected With Salmonella Enteritidis 11rx

Cited by 6 publications

References 2 publications

RECALL OF TUMOUR RESISTANCE IN LONG‐TERM SALMONELLA ENTERITIDIS 11RX IMMUNISED MICE

RECALL OF TUMOUR RESISTANCE IN LONG‐TERM SALMONELLA ENTERITIDIS 11RX IMMUNISED MICE

Further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with Corynebacterium parvum

FACTORS AFFECTING THE ABILITY OF VARIOUS STRAINS OF ENTEROBACTERIACEAE TO INDUCE TUMOUR RESISTANCE IN MICE

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