Tumour regression following stem cell infusion from daughter to microchimeric mother

Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism

“…The presence of the recipient-specific long-term microchimerism presumed to be of maternal or fetal origin was confirmed in all the donors with IPA-or NIMA-specific nested polymerase chain reactions (PCRs) using sequencespecific primers as previously described. 26,31 No patients were reported to be positive for antidonor lymphocyte antibodies before transplantation.…”

High doses of mother's lymphocyte infusion to treat EBV-positive T-cell lymphoproliferative disorders in childhood

“…Recent experimental evidences show the association between microchimerism and acquired immune hyporesponsiveness, which is useful for solid-organ transplantation and hematopoietic stem cell transplantation (HSCT). 18,19 The long-term child-maternal microchimerism as a form of acquired child-maternal tolerance was first proposed by Tokita et al 20 They reported the dramatic regression of thymic carcinoma in a mother who received an infusion of peripheral blood stem cells from her HLA-haploidentical daughter without any signs of GVHD. Microchimerism of donor's alleles in the recipient were detected before and long after the infusion, prompting them to speculate that the mother had been tolerant to the inherited paternal antigens (IPAs); thus, the infused effector lymphocytes from her daughter survived longer in the face of the maternal immune system.…”

Non-T-cell-depleted HLA haploidentical stem cell transplantation based on feto-maternal microchimerism in pediatric patients with advanced malignancies

“…3,7 As summarized in Table 1, IPAs of the patients were detected in the peripheral blood of the mothers (cases 3-6, 8 and 9) and NIMA was detected in the peripheral blood of the donors (cases 2 and 10), suggesting immunologic tolerance to the recipient cells. IPA of two patients (cases 7 and 11) was undetectable in the peripheral blood of the donors.…”