Tumour promoter activity in Malaysian Euphorbiaceae

Norhanom, A. W.; Yadav, M

doi:10.1038/bjc.1995.150

Cited by 11 publications

(5 citation statements)

References 15 publications

(19 reference statements)

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“…It is important to note that the research conducted by Norhanom and Yadav in 1995 described the tumour-promoting activity of several Malaysian plants belonging to the Euphorbiaceae family, including Euphorbia atoto, which was tested in vitro on a human lymphoblastoid cell line harbouring the Epstein-Barr virus (EBV) genome. Based on this observation, the authors pointed out that regular use of E. atoto could well be an etiological factor for the promotion of tumours among rural Malaysian peoples [27].…”

Section: Resultsmentioning

confidence: 95%

Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis of Euphorbia atoto

Wirasisya,

Kincses,

Vidács

et al. 2023

Plants

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Indonesia is among the countries with the most significant biodiversity globally. Jamu, the traditional medicine of Indonesia, predominantly uses herbal materials and is an integral component of the Indonesian healthcare system. The present study reviewed the ethnobotanical data of seven Indonesian Euphorbiaceae species, namely Euphorbia atoto, E. hypericifolia, Homalanthus giganteus, Macaranga tanarius, Mallotus mollissimus, M. rufidulus, and Shirakiopsis indica, based on the RISTOJA database and other literature sources. An antimicrobial screening of the plant extracts was performed in 15 microorganisms using the disk diffusion and broth microdilution methods, and the antiproliferative effects were examined in drug-sensitive Colo 205 and resistant Colo 320 cells by the MTT assay. The antimicrobial testing showed a high potency of M. tanarius, H. giganteus, M. rufidulus, S. indica, and E. atoto extracts (MIC = 12.5–500 µg/mL) against different bacteria. In the antitumour screening, remarkable activities (IC50 0.23–2.60 µg/mL) were demonstrated for the extracts of H. giganteus, M. rufidulus, S. indica, and E. atoto against Colo 205 cells. The n-hexane extract of E. atoto, with an IC50 value of 0.24 ± 0.06 µg/mL (Colo 205), was subjected to multistep chromatographic separation, and 24-methylene-cycloartan-3β-ol, jolkinolide E, tetra-tert-butyl-diphenyl ether, α-tocopherol, and β-sitosterol were isolated.

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Section: Resultsmentioning

confidence: 95%

Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis of Euphorbia atoto

Wirasisya,

Kincses,

Vidács

et al. 2023

Plants

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“…E. prostrata at a dose of 750 mg relieved the symptoms of bronchial asthma [ 42 ] while in a dose of 100 mg once daily for 14 days, it is useful in ameliorating the signs and symptoms associated with hemorrhoids [ 43 , 44 ]. There are several studies on a possible tumor promoter activity of E. milii chemical constituents [ 45 – 47 ]; however, an in-vivo study contradicts this activity [ 32 ]. Moreover, the tumor induction property of various species of Euphorbia is a long-term effect and is not a concern for their short term use after in-vivo administration.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii

Islam

Khan

Rauf

et al. 2015

BMC Complement Altern Med

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BackgroundNanotechnology has potential future for enhancing therapeutic efficacy and reducing the unwanted effects of herbal drugs. The biological research on Euphorbia species has been supported by the use of some plants in traditional medicines. Many species of Euphorbia have been reported as having strong sedative and analgesic effects. In the present research work gold nanoparticles of Euphorbia milii methanolic extract (Au-EM) were synthesized, characterized and tested for antinociceptive, muscle relaxant and sedative activities.MethodsAu-EM was prepared by stirring 1 mM warm trihydrated tetrachloroaurate solution with E. milii methanolic extract without using any external reducing agents. The gold nanoparticles were characterized by UV-Visible spectroscopy, infrared spectrophotometery, atomic force microscopy and scanning electron microscopy while their stability was evaluated against varying pH and different volumes of sodium chloride (NaCl). The metal sensing capacity of Au-EM was tested towards cobalt, copper, lead, mercury and nickel. Au-EM was evaluated in BALB/c mice at a dose of 10 and 20 mg/kg for antinociceptive, muscle relaxant and sedative activities in comparison with the crude E. milii methanolic extract.ResultsAu-EM showed remarkable stability in different NaCl and pH solutions. Au-EM produced significant (P < 0.01) antinociceptive effect at doses of 10 and 20 mg/kg as compared to the crude E. milii methanolic extract. In the rotarod test, Au-EM showed significant muscle relaxant effect at 10 mg/kg (P < 0.05) and 20 mg/kg (P < 0.01) after 30, 60 and 90 min. In an open field test significant sedative effect (P < 0.05) of Au-EM was observed at 10 and 20 mg/kg. Moreover significant detection sensitivity was demonstrated towards all the tested heavy metals.ConclusionsThese results concluded that the gold nanoparticles improved the potency of E. milii methanolic extract and exhibited significant analgesic, muscle relaxant and sedative properties. The significant metals sensing ability and enhanced stability in different NaCl and pH solutions may enable us to explore different formulations of E. milii gold nanoparticles for potentially effective and safe nano-herbal therapy.

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“…Cytotoxicity of methanol extracts and alkaloids content of C. variegatum Petra were assessed against hepatocellular carcinoma, human Caucasian breast adenocarcinoma, colon cell line and lung carcinon and proved to be active with activity range of 17.3% -98% (Hassan et al, 2013). While in Malaysian cultivars, tumour-promotor activity was observed in human lymphoblastoid cell line harbouring the Epstein-Barr virus (EBV) genome, Notice from the regular users of this plant (Norhanom and Yadav, 1995).…”

Section: Petra Gold Dustmentioning

confidence: 99%

EFFECTS OF DIFFERENT CROTON (Codiaeum variegatum L.) GENOTYPES AND GROWTH REGULATORS ON CALLUS INDUCTION, MICRO PROPAGATION AND ANTIBACTERIAL ACTIVITIES

Bakheet

Soliman

Abdelkader

et al. 2018

Zagazig Journal of Agricultural Research

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The Main aim of this study was determine the effect of different croton (Codiaeum variegatum) genotypes (Gold Dust and Petra) and growth hormones on callus induction, micro propagation and antibacterial activities. Murashige and skoog (MS) medium with four compositions of growth hormones for callus induction, mursh M1 (2 mg/l 2, 4 Dichlorophenoxy acetic acid (2, 4-D), M2 (3 mg/l 2, 4-D), M3 (2mg/l 1-Naphthalen acetic acid (NAA), M4 (1mg/l 2, 4-D + 1 mg/l NAA) were used. For micro propagation, four different hormone balance were used, i.e., M1 (1 mg/l Benzyl adenine (BA) + 25 mg/l peptone), M2 (1mg/l BA + 50mg/l peptone), M3 (3mg/l BA + 25mg/l peptone), M4 (3mg/l BA + 50mg/l peptone).For rooting induction the combinations of growth regulators were used as follows, Mr1 (1mg/lIndolbuteric acid(IBA), Mr2 (2mg/l IBA), and Mr3 (1mg/l IBA+ 1mg/l NAA). Results showed that the highest genetic response for callus induction frequencies were seen for Petra genotype (91.25%) followed by Gold Dust. Medium M3 showed the highest response for callus induction frequencies (82.4%) followed by M1.Interaction between genotypes and media each alone were highly significant in callus fresh weight character. Regarding the micro propagation, Petra genotype gave highly genetic response followed by Gold Dust, also medium (M1) gave highly response for micro propagation followed by M2. In vitro roots were successfully induced by (1 or 2) mg/l of IBA which gave longest and few roots, while 1mg/l NAA gave shorter and more root number. Plants with roots were moved to the green house for acclimatize in pots contain sand /farmyard manure (8:2VN). Alkaloids extracted from callus for both genotypes were detected for antibacterial activities against Gram positive and negative bacteria. Alkaloids extracted from calli for media M1 and M2 were gave a highest antibacterial activity. Finally the present results gives scientific evidence on the ideal composition of the media to product the alkaloid extracts from C. variegatum (Gold Dust and Petra) as medicinal plants to be used as antibacterial agents against different pathogens.

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Tumour promoter activity in Malaysian Euphorbiaceae

Cited by 11 publications

References 15 publications

Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis of Euphorbia atoto

Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis of Euphorbia atoto

Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii

EFFECTS OF DIFFERENT CROTON (Codiaeum variegatum L.) GENOTYPES AND GROWTH REGULATORS ON CALLUS INDUCTION, MICRO PROPAGATION AND ANTIBACTERIAL ACTIVITIES

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