Tumour‐positive sentinel node findings in patients with ductal carcinoma in situ

Abstract

Metastatic SN findings in patients with pure DCIS may be a sign of missed invasion.

Meta-analysis of sentinel node biopsy in ductal carcinomain situof the breast

“…Advocates of SLN biopsy in DCIS at the time of excision suggest that SLN biopsy may not be reliable after tumour excision and that patients should undergo an axillary lymph node dissection if a SLN biopsy was not performed at the time of the first operation 52 . However, others argue that SLN biopsy can be performed Reference Cserni 39 Kelly et al 20 Intra et al 21 Farkas et al 22 Veronesi et al 40 Zavagno et al 23 Katz et al 30 Mabry et al 15 Leidenius et al 41 Sakr et al 42 Di Saverio et al 43 Overall 0·100 0·023 0·031 0·011 0·018 0·020 0·073 0·059 0·068 0·103 0·125 0·037 0·005 0·050 0·500…”

Predicting invasion in patients with DCIS in the preoperative percutaneous biopsy

“…Both the SN and the lymph nodes in the AC specimens were histologically assessed as described in our previous study [8].…”

Microinvasive Carcinoma of the Breast

“…Simpson et al [32] 1992 Foci of stromal invasion, maximum size not specified 5 1 (20) Solin et al [16] 1992 Invasion less than or equal 2 mm or comprising less than 10% of the tumour [45] 2003 1 focus or more foci, each less or equal to 1 mm 41 a 4 (9.7) Yang et al [46] 2003 1 focus or more foci, each less or equal to 1 mm 26 0 Buttarelli et al [47] 2004 1 focus or more foci, each less or equal to 1 mm 11 a 1 (9.1) Giard et al [48] 2005 1 focus or more foci, each less or equal to 1 mm 32 a 1 (1.1) Wilkie et al [49] 2005 1 focus or more foci, each less than 1 mm 51 a 7 (13.7) Katz et al [50] 2006 1 focus or more foci, each less or equal to 1 mm 21 a 2 (9.5) Leidenius et al [51] 2006 1 focus or more foci, each less or equal to 1 mm 11 a 1 (9.0) Gray et al [52] 2007 1 focus or more foci, each less or equal to 1 mm 81 a 6 (7.4) Le Bouedec et al [53] 2007 1 focus or more foci, each less or equal to 1 mm 40 a 4 (10%) Zavagno et al [54] 2007 1 focus or more foci, each less or equal to 1 mm 43 a 4 (9.3) a Series with sentinel lymph node biopsy 20% (9-11, 15-18, 31-54; Table 1). This wide range may be explained by both the different histopathological criteria used to define what constitutes microinvasion and the variable degrees of breast tissue sampling, but also it depends on the different techniques utilized to stain axillary lymph nodes (hematoxylin and eosin or IHC) especially after the introduction of sentinel lymph node (SLN) biopsy.…”