Tumour pH

Stubbs, Marion

doi:10.1007/978-3-642-58813-6_11

Cited by 9 publications

(6 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If the fraction of binary MACHOs is as high as that of binary stars, 5 ∼ 10 % of events are expected to be a caustic crossing event (Mao & Paczynski 1991). Thus, one can expect a caustic crossing event per a few year even with the current microlensing search, and if the next generation microlensing search is launched, the expected number of such an event will be increased by two order of magnitudes (Stubbs 1998). Therefore in a decade or so, we may be able to measure the MACHO mass for a number of events by combining the ground-based monitoring and the HST or other space telescope in the next generation.…”

Section: Discussionmentioning

confidence: 99%

MACHO Mass Determination Based on Space Telescope Observation

Honma¹

1999

The Astrophysical Journal

View full text Add to dashboard Cite

We investigate the possibility of lens mass determination for a caustic crossing microlensing event based on a space telescope observation. We demonstrate that the parallax due to the orbital motion of a space telescope causes a periodic fluctuation of the light curve, from which the lens distance can be derived. Since the proper motion of the lens relative to the source is also measurable for a caustic crossing event, one can find a full solution for microlensing properties of the event, including the lens mass. To determine the lens mass with sufficient accuracy, the light curve near the caustic crossing should be observed within uncertainty of ∼1%. We argue that the Hubble Space Telescope observation of the caustic crossing supplied with ground-based observations of the full light curve will enable us to determine the mass of MACHOs, which is crucial for understanding the nature of MACHOs.

show abstract

Section: Discussionmentioning

confidence: 99%

MACHO Mass Determination Based on Space Telescope Observation

Honma¹

1999

The Astrophysical Journal

View full text Add to dashboard Cite

show abstract

“…However, as for the TBF effects induced by hyperthermia, further investigations are required to define the real effects (short-or long-lasting oxygenation) as well as the underlying mechanisms [139]. Concerning tumor pH, one has to differentiate the extracellular pH (pH e ) from the intracellular one (pH i ) [136,149]. The effects of heating seemed to favor a decrease of both pH i and pH e , which in turn leads to an improvement of hyperthermia by sensitizing tumor cells [139].…”

Section: Tumor Metabolic Microenvironmentmentioning

confidence: 99%

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Mohamed

Borchard

Jordan

2012

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

Hyperthermia, an established adjuvant in cancer treatment, potentiates the effects of anticancer drugs and synergetic combination can be obtained improving the therapeutic outcome. Bone metastases may benefit from this combination when treated through in situ forming implants. Once loaded with magnetizable (nano-) particles and antineoplastic agents, these implants allow for the local application of magnetically-induced hyperthermia and the release of an anticancer drug. The implant can be heated applying an external magnetic field, sensitizing the surrounding tumoral tissues, while releasing the chemotherapeutic agent.Moreover, bone implants provide mechanical support to the weakened bone and consequently relieve pain.This review gives an overview of the current knowledge as well as the rationale of combining locally both magnetic hyperthermia and chemotherapy using in situ forming implants in the field of bone metastases treatment. KeywordsInduced hyperthermia, chemotherapy, drug delivery systems, in situ forming implants, iron oxide nanoparticles, bone metastases, cementoplasty, vertebroplasty 3

show abstract

“…Of the eight microlensing events detected by Alcock et al (1997b) during their first two years of observations, none of the sources were brighter than V = 20 (after removing blended light) which is the nominal limit for SIM. Future microlensing surveys could improve the rate of detection by an order of magnitude (Gould 1999b;Stubbs 1998). However, only a factor of three of this improvement would be due to the coverage of a larger area.…”

Section: Lmcmentioning

confidence: 99%

Photometric Microlens Parallaxes with theSpace Interferometry Mission

Gould

Salim

1999

ApJ

View full text Add to dashboard Cite

Astrometric measurements of microlensing events can in principle determine both the "parallax"r E and the "proper motion" µ of an individual event which (combined with the Einstein time scale t E ) in turn yield the mass, distance, and transverse velocity of the lens. We show, however, that the parallax measurements are generically several orders of magnitude less precise than the proper-motion measurements. Fortunately, astrometric measurements by the Space Interferometry Mission (SIM) are simultaneously photometric measurements, and since SIM will be in solar orbit, these allow SIM to be used as a classical (photometric) parallax satellite. We show that SIM photometric parallaxes are of comparable precision to its astrometric proper-motion measurements. For I = 15 bulge stars, complete solutions with ∼ 5% accuracy in mass, distance, and transverse velocity can be obtained from about 5 hours of observation, 100 to 10,000 times shorter than would be required for a purely astrometric solution of similar precision. Thus, it should be possible to directly measure the mass functions of both the bulge and the inner disk (including both dark and luminous objects) with only a few hundred hours of SIM observations.

show abstract

Tumour pH

Cited by 9 publications

References 49 publications

MACHO Mass Determination Based on Space Telescope Observation

MACHO Mass Determination Based on Space Telescope Observation

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Photometric Microlens Parallaxes with theSpace Interferometry Mission

Contact Info

Product

Resources

About