Tumour necrosis factor-α induces cyclo-oxygenase-2 gene expression in first trimester trophoblasts: suppression by glucocorticoids and NSAIDs

New Trends in Dual 5-LOX / COX Inhibition

“…In patients with knee arthrosis, appeared active in vivo in the carrageenan-induced paw edema in rats and inhibited the PMN infiltration with an ED 50 of 1.3 mg/kg p.o. in a model of arachidonic acid-induced ear inflammation in mice [36]. ER-34122 also showed antiinflammatory activity in the early stage of spontaneous arthritis using a model of progression of articular lesions in mice [183].…”

“…Indeed, COX-2 expression can be induced in many cell types by bacterial endotoxin [30,31,32], cytokines such as IL-1 [33,34], IL-17 [35] or TNFα [36,37], growth factors such as EGF [38,39], or mitogens such as phorbol esters [40]. It should be noted that COX-1 levels are also increased in several cell types by IL-1 and phorbol ester, although the magnitude of the response to those two stimuli is very weak [28].…”

Risk of preterm delivery and small-for-gestational-age births in women with autoimmune disease using biologics before or during pregnancy: a population-based cohort study

“…In pregnancy, TNF-alpha controls cyclo-oxygenases that affect blastocyst implantation, endometrial permeability and decidualisation,6 and contributes to the process of labour 7. Abnormally high levels of TNF-alpha and other cytokines have been implicated in pregnancy complications including preterm delivery, fetal growth retardation, early and unexplained spontaneous abortions, and miscarriages 7–10.…”

Drug therapy in patients with rheumatic diseases during pregnancy and lactation

“…Исследования на мышиных моде-лях показали, что это один из нескольких цитокинов, влияющих на развитие беременности на ранних сроках [162]. Вызывая экспрессию гена ЦОГ 2 на ранней стадии беременности [163], ФНО α контролирует ЦОГ и таким об-разом влияет на имплантацию бластоцисты, сосудистую проницаемость эндометрия и маточную децидуацию. ФНО α, наряду с другими воспалительными цитокинами, участвует в развитии родов: индуцирует сокращения матки [164].…”