Tumour necrosis factor alpha (TNFα) and alpha-Klotho (αKL) in children and adolescents with chronic kidney disease (CKD)

Abstract

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Serum Levels of α-Klotho, Inflammation-Related Cytokines, and Mortality in Hemodialysis Patients

“…Yildirim et al [ 26 ] have demonstrated that HD and PD patients have higher serum α-Klotho than healthy people. In a recent study by Gamrot et al [ 27 ], mean serum α-Klotho was higher in children with CKD on dialysis than in conservatively treated children. Drüeke et al [ 28 ] suggested that there might be a difference in Klotho levels between patients supplemented with vitamin D and those not receiving vitamin D. In our study, approximately half of the patients were supplemented with alfacalcidol.…”

“…In PD patients, high concentrations of Klotho (above the median value of 329 pg/mL) were associated with lower IL-6 levels [ 17 ]. In children with CKD, no correlation was observed between serum α-Klotho or TNF-α concentration and any measured anthropometric and laboratory parameters [ 27 ]. In our study, α-Klotho also positively correlated with IL-12p70, IL-10, and IL-1β but not with TNF or IL-6.…”

“…Its soluble form results from direct secretion by the cell of truncated form or from cleavage of the extracellular domain of the full-length protein [ 5 ]. The different tissue locations of α-Klotho and the different mechanisms of soluble Klotho production bring into question the relationship between protein expression in the kidney and its amount in the blood in CKD patients [ 11 , 25 , 26 , 27 ]. The lack of relationship between serum α-Klotho and fatal or non-fatal cardiovascular events could be explained by several factors.…”

A sinalização tnf-alfa-tnfr1 regula diferencialmente a perda óssea periapical e a neoformação dentinária em modelo experimental murino

“…O TNF-α é uma importante citocina pró-inflamatória que está envolvida no processo de perda óssea (Xu et al, 2018). É sintetizado por macrófagos e outros tipos celulares imunocompetentes, e seu papel é regular e coordenar alguns processos celulares que estão relacionados a resposta imune durante uma inflamação (Gamrot et al, 2021). Possui dois tipos Capítulo 1 | 22 de receptores principais que são o TNFR1 ou P-55 e TNFR2 ou P-75 (Tacchini-Cottier et al, 1998;Gamrot et al, 2021).…”

“…É sintetizado por macrófagos e outros tipos celulares imunocompetentes, e seu papel é regular e coordenar alguns processos celulares que estão relacionados a resposta imune durante uma inflamação (Gamrot et al, 2021). Possui dois tipos Capítulo 1 | 22 de receptores principais que são o TNFR1 ou P-55 e TNFR2 ou P-75 (Tacchini-Cottier et al, 1998;Gamrot et al, 2021). O TNFR1 é expresso em quase todas as células existentes e possui sua forma trimétrica antes da estimulação pelo TNF-α.…”