Tumour necrosis factor alpha down-regulation parallels inflammatory regression in ulcerative colitis patients treated with infliximab

Elevation of PRKCDBP, A Novel Transcriptional Target of TNF-α, and Its Downregulation by Infliximab in Patients with Ulcerative Colitis

“…Clinical outcomes in the first year after IFX treatment, including steroid withdrawal, colectomy, hospitalization, and clinical remission, were more favorable in the low pre-PRKCDBP group, albeit not significantly so ( Table 6). Discussion TNF-a is a critical proinflammatory cytokine, and its downregulation in the colonic mucosa is associated with regressed inflammation in patients with moderate-to-severe UC [13,15]. A recent study showed that PRKCDBP, a proapoptotic tumor suppressor gene, is a direct transcriptional target of TNF-a/NF-jB signaling, and its expression is frequently lost or downregulated in human colorectal cancer [22].…”

“…Other studies have shown that IFX reduces TNF-a tissue levels according to the clinical response [14,15]. The Leuven group recently published a study on the predictive value of colonic mucosal gene expression for the response to IFX therapy in patients with UC, and identified a panel of proteins that separated responders from non-responders with 89 % accuracy [16].…”

Tumour Necrosis Factor Alpha in Segmental Colitis Associated with Diverticula

“…Furthermore, a profound down-regulation of TNF-a in the affected mucosa has been associated with a dramatic improvement, as assessed both histologically and clinically, after infliximab therapy, thereby providing additional support for the importance of this cytokine in IBD pathogenesis [14,19].…”

“…Tumour necrosis factor alpha (TNFa) -a 17-kDa polypeptide produced by macrophages, lymphocytes and natural killer cells -has been shown to play a major role in this process, with high levels being found in IBD patients [8][9][10]. Although this cytokine has been primarily implicated in the pathogenesis of type 1 helper T (Th1) cell-mediated disorders, such as CD and rheumatoid arthritis [11,12], high levels of TNF-a have also been shown in the blood, stool and intestinal tissues of patients with ulcerative colitis, suggesting a possible role even in type 2 helper T (Th2) cell-mediated diseases [13,14].…”

Altered molecular pattern of mucosal healing in Crohn’s disease fibrotic stenosis

“…Considerable downregulation of tumor necrosis factor-α (TNF-α) may occur after infliximab therapy in inflammatory bowel diseases (IBD) in those patients who achieve disorder remission (responders: about the 70%) [1] . Such downregulation may be associated with a dramatic regression of endoscopic lesions with a feature suitable of "mucosal healing'' [2] .…”