2014
DOI: 10.1590/0074-0276130372
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Tumour necrosis factor -308 and -238 promoter polymorphisms are predictors of a null virological response in the treatment of Brazilian hepatitis C patients

Abstract: Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs in the promoters of interleukin (IL)-10 (-1082 A/G, rs1800896), myxovirus resistance protein 1 (-123 C/A, rs17000900 and -88 G/T, rs2071430) and tumour necrosis factor (TNF) (-308 G/A, rs1800629 and -238 G/A, rs361525) genes and the outcome of PEGylated α-interferon plus ribavirin therapy were investigated. This analysis was per… Show more

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Cited by 7 publications
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“…Although some studies have reported a significant association between TNF polymorphism and response to hepatitis C treatment, some studies reported (24) from Taiwan suggested that TNF polymorphism at position-308 may be a predictor of treatment failure in patients treated with a combination of IFN-α and RBV and in another study from Brazil, the TNF-α-308 a allele was found to be a predictor of null virological response (25,26), but other investigations have failed to confirm such findings. An Egyptian study found that at the TNF-α 308 position, the G/G allele was most common (78.5%) in the study population compared to controls (27).…”
Section: Discussionmentioning
confidence: 99%
“…Although some studies have reported a significant association between TNF polymorphism and response to hepatitis C treatment, some studies reported (24) from Taiwan suggested that TNF polymorphism at position-308 may be a predictor of treatment failure in patients treated with a combination of IFN-α and RBV and in another study from Brazil, the TNF-α-308 a allele was found to be a predictor of null virological response (25,26), but other investigations have failed to confirm such findings. An Egyptian study found that at the TNF-α 308 position, the G/G allele was most common (78.5%) in the study population compared to controls (27).…”
Section: Discussionmentioning
confidence: 99%
“…Several studies show opposite results concerning the role of TNF-α rs1800629 in the natural course and antiviral therapy for chronic hepatitis C [ 25 27 ]. The results show the absence of any TNF-α-308G/A influence on the natural course and treatment outcome of chronic hepatitis C and suggest a modification of HCC development risk [ 28 ].…”
Section: Introductionmentioning
confidence: 99%