Tumour microenvironment and aberrant signaling pathways in cisplatin resistance and strategies to overcome in oral cancer

Biswal, Stuti; Panda, Munmun; Sahoo, Rajeev K; Tripathi, S. K.; Biswal, Bijesh K.

doi:10.1016/j.archoralbio.2023.105697

Cited by 9 publications

(4 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complex 1 enhanced the accumulation of cells in the sub-G1 and G0/G1 phases, while decreasing the DNA synthesis rate. The impact of 1 on the distribution of the cell cycle appears to resemble that of the previously evaluated iridium(III), [Ir(η 5 [33][34][35]. The pattern of cell cycle arrest promoted by compound 1 is often accompanied by concomitant or subsequent apoptotic cell death induction.…”

Section: Complex 1 Triggers Apoptosis In 8505c Cellsmentioning

confidence: 57%

“…Cisplatin has been widely used as the "gold standard" in cancer treatment for over 60 years [1][2][3][4]. Despite its success in treating various types of cancers, cisplatin has certain limitations, including the development of resistance and severe toxic effects, such as kidney, ear, and brain damage [5][6][7]. Platinum-based drugs, such as cisplatin, carboplatin, and oxaliplatin, have been widely used as effective chemotherapeutic agents in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand

Ludwig,

Ranđelović,

Dimić

et al. 2024

Biomolecules

View full text Add to dashboard Cite

The (pentamethylcyclopentadienyl)chloridoiridium(III) complex bearing a κP,κS-bonded Ph2PCH2CH2SPh ligand ([Ir(η5-C5Me5)Cl(Ph2P(CH2)2SPh-κP,κS)]PF6, (1)] was synthesized and characterized. Multinuclear (1H, 13C and 31P) NMR spectroscopy was employed for the determination of the structure. Moreover, SC-XRD confirmed the proposed structure belongs to the “piano stool” type. The Hirshfeld surface analysis outlined the most important intermolecular interactions in the structure. The crystallographic structure was optimized at the B3LYP-D3BJ/6-311++G(d,p)(H,C,P,S,Cl)/LanL2DZ(Ir) level of theory. The applicability of this level was verified through a comparison of experimental and theoretical bond lengths and angles, and 1H and 13C NMR chemical shifts. The Natural Bond Orbital theory was used to identify and quantify the intramolecular stabilization interactions, especially those between donor atoms and Ir(III) ions. Complex 1 was tested on antitumor activity against five human tumor cell lines: MCF-7 breast adenocarcinoma, SW480 colon adenocarcinoma, 518A2 melanoma, 8505C human thyroid carcinoma and A253 submandibular carcinoma. Complex 1 showed superior antitumor activity against cisplatin-resistant MCF-7, SW480 and 8505C cell lines. The mechanism of tumoricidal action on 8505C cells indicates the involvement of caspase-induced apoptosis, accompanied by a considerable reduction in ROS/RNS and proliferation potential of treated cells.

show abstract

Section: Complex 1 Triggers Apoptosis In 8505c Cellsmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand

Ludwig,

Ranđelović,

Dimić

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

“…1A). As extensive research is available for the PI3K-Akt, MAPK, and Jak-STAT signaling pathways [39,40], our investigation focused on understanding the mechanisms responsible for how the Hippo signaling pathway contributes to platinum resistance in oral cancer. Examination of the key DEGs related to Hippo signaling pathway revealed high YAP expression in all six platinum-resistant samples (Fig.…”

Section: Clinicopathological Characteristics Of Yap In Human Oscc Tissuementioning

confidence: 99%

Circular RNA hsa_circ_00027220-induced regulation of Yes-associated protein promotes platinum resistance in oral squamous cell carcinoma: implications for verteporfin therapy

Tsai,

Hua

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose: Oral squamous cell carcinoma (OSCC) significantly impacts public health with its high occurrence and grim outcomes. Platinum resistance complicates OSCC treatment. Yes-associated protein (YAP) plays a key role in OSCC development, while circular RNA (circRNA) influences microRNA activity, contributing to chemoresistance in cancers. Yet, how circRNA affects YAP expression in OSCC is unclear. Methods: We examined the expression of YAP in 21 newly diagnosed OSCC cases using immunohistochemistry and quantitative polymerase chain reaction (qPCR). Cisplatin-resistant OSCC cell lines were established for further investigation. A luciferase reporter system, RNA pull-down assay, and RNA fluorescence in situ hybridization (FISH) assay were utilized to demonstrate that circRNA hsa_circ_0002722 (circ_0002722) could bind to microRNA-1305 (miR-1305). The synergistic effects of combined cisplatin and verteporfin (a YAP inhibitor) treatment were evaluated using SynergyFinder. We also developed subcutaneous tumorigenicity graft models to validate our findings in an in vivo setting. Results: Here, we found that YAP and circ_0002722 were upregulated in platinum-resistant OSCC tissues. Circ_0002722 acted as a regulator of miR-1305, influencing YAP expression and thereby mediating platinum sensitivity. In vivo experiments corroborated the synergistic effects of cisplatin and verteporfin in combating platinum resistance. Therefore, targeting YAP is a promising therapeutic strategy for addressing platinum resistance in OSCC, with circ_0002722 serving as a potential therapy target and valuable diagnostic marker. Conclusions: These findings provide novel insights into the underlying mechanisms of platinum resistance and suggest new avenues for developing effective treatment approaches in OSCC.

show abstract

“…However, drug resistance during treatment limits long-term efficacy. In particular, drug resistance is driven by complex changes in cell signaling pathways (Jha et al, 2023;Trocchianesi et al, 2023), as well as the tumor microenvironment (Biswal et al, 2023;Qiao et al, 2023;Zhang et al, 2023). Therefore, an in-depth understanding and study of the molecular basis of drug resistance is essential for the development of more effective therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Decoding the research landscape of drug resistance and therapeutic approaches in head and neck cancer: a bibliometric analysis from 2000 to 2023

Han,

Shi,

Liu

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Introduction:Head and neck cancer is one of the most common tumors worldwide. However, drug resistance in its treatment has become a major factor limiting the efficacy. This study aims to comprehensively understand the current status of research in this field.Methods:The study analyzes papers related to therapeutic resistance in head and neck cancer published between 2000 and 2023 in the Web of Science Core Collection To achieve the research objectives, we searched the WoSCC for research and review papers on therapeutic resistance in head and neck cancer from 2000 to 2023, screened the English literature, and analyzed the research hotspots, academic collaborations, and trends in detail using tools such as Citespace, SCImago Graphica, and VOS viewer.Results:This study summarizes 787 head and neck cancer treatment resistance publications from WoSCC. The analysis showed that China and the United States are the major contributors in this field, and Grandis Jennifer R and Yang Jai-Sing are the key scholars. Keyword analysis showed that “cisplatin resistance” is a continuing focus of attention, while “Metastasis” and “Ferroptosis” may be emerging research hotspots. Literature clustering analysis pointed out that “Ferroptosis”, “Immunotherapy” and “ERK signaling” were the recent hotspots that received extensive attention and citations. Finally, we discuss the current status and challenges in drug-resistant therapies for head and neck cancer.Conclusion:This study is the first comprehensive bibliometric analysis of drug resistance in head and neck cancer. Reveals current trends and helps researchers grasp cutting-edge hotspots in the field.

show abstract

Tumour microenvironment and aberrant signaling pathways in cisplatin resistance and strategies to overcome in oral cancer

Cited by 9 publications

References 90 publications

(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand

(Pentamethylcyclopentadienyl)chloridoiridium(III) Complex Bearing Bidentate Ph2PCH2CH2SPh-κP,κS Ligand

Circular RNA hsa_circ_00027220-induced regulation of Yes-associated protein promotes platinum resistance in oral squamous cell carcinoma: implications for verteporfin therapy

Decoding the research landscape of drug resistance and therapeutic approaches in head and neck cancer: a bibliometric analysis from 2000 to 2023

Contact Info

Product

Resources

About