Tumour malignancy loss and cell differentiation are associated with induction of<i>gef</i>gene in human melanoma cells

Boulaiz, Houría; Prados, José; Melguizo, Consolación; Marchal, Juan A.; Carrillo, Esmeralda; Perán, Macarena; Rodríguez-Serrano, Fernando; Martínez‐Amat, Antonio; Caba, Octavio; Hita, Fidel; Concha, Ángel; Aránega, Amelia

doi:10.1111/j.1365-2133.2008.08688.x

Cited by 12 publications

(11 citation statements)

References 41 publications

(42 reference statements)

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“…As our understanding of the pathogenesis, pathology and natural history of melanomas are improving, a consensus is emerging that dysplastic naevi do not represent a precursor of melanoma. [42][43][44][45][46][47][48][49][50][51][52][53][54][55] Instead, it is suggested that some dysplastic naevi (and especially severely dysplastic naevi) may in fact be early melanomas that we are not able to diagnose at present (rather than melanoma precursors as such). The issue was passionately contested but it was agreed that melanomas can frequently arise de novo or from banal moles, and any patients with multiple moles rather than dysplastic naevi per se has a risk factor for melanoma.…”

Section: Cutaneous Oncologymentioning

confidence: 87%

“…Melanoma is an aggressive malignancy and a significant effort has been directed towards the improvement of its prevention, diagnosis and treatment 1–41 . As our understanding of the pathogenesis, pathology and natural history of melanomas are improving, a consensus is emerging that dysplastic naevi do not represent a precursor of melanoma 42–55 . Instead, it is suggested that some dysplastic naevi (and especially severely dysplastic naevi) may in fact be early melanomas that we are not able to diagnose at present (rather than melanoma precursors as such).…”

Section: Cutaneous Oncologymentioning

confidence: 99%

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Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology

Alexandroff

Burd

2009

British Journal of Dermatology

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The 17th Congress of the European Academy of Dermatology and Venereology took place in Paris on 17-20 September 2008 and brought together nearly 11,000 participants. Various plenary lectures, subspecialty meetings, 'free communications', 'top ten', 'test yourself' and 'junior' sessions, 19 courses and 14 'lunches with the expert', six forums, 27 symposia and 45 workshops were pressed into the 4 days of the meeting. Over 1700 posters were presented and exhibited. The themes of a number of symposiums, workshops and sessions overlapped, offering additional educational opportunities despite a very busy schedule. The meeting was well organized. Aesthetic dermatology comprised a significant part of the meeting. It is impossible to encompass all important presentations and we highlight a few medical pearls presented at the meeting; however, our report is not intended as a substitute for reading the conference proceedings and related references quoted in this article.

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Section: Cutaneous Oncologymentioning

confidence: 87%

Section: Cutaneous Oncologymentioning

confidence: 99%

Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology

Alexandroff

Burd

2009

British Journal of Dermatology

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“…For example, expression of the HokC toxin from E. coli was induced in melanoma (31), breast (32), and lung (33) cancer cell lines. This toxin showed promise in hindering the growth and proliferation of these malignant cells.…”

Section: Discussionmentioning

confidence: 99%

Decoding Toxicity

Mok¹,

Patel

2010

Journal of Biological Chemistry

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Bacterial genomes encode a collection of small peptides that are deleterious to their hosts when overexpressed. The physiological relevance of the majority of these peptides is unknown at present, although many of them have been implicated in regulatory processes important for cell survival and adaptability. One peptide that is of particular interest to us is a 19-amino acid proteic toxin, coined IbsC, whose production is repressed by SibC, an RNA antitoxin. Together, IbsC and SibC constitute a type I toxin-antitoxin (TA) pair. To better understand the function of IbsC and to decipher the sequence determinants for its toxic phenotype, we carried out extensive sequence analyses of the peptide. We generated a series of truncation and single amino acid deletion mutants to determine the minimal sequence required for toxicity. We further probed into functionally relevant amino acids with a comprehensive set of IbsC mutants produced using a systematic sequence randomization strategy. We found that IbsC remained toxic in the presence of multiple deletions and single amino acid substitutions, despite being well-conserved in Escherichia coli and across other Gram-negative bacteria. The toxicity of this peptide was determined to be dependent on a stretch of highly hydrophobic residues near its center. Our results defined sequence-function relationship of IbsC and offered additional insights into properties common to membrane-targeting type I toxins in E. coli and related species.

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“…Malignant melanoma kills a disproportionately large number of young people, and it is not surprising that significant and sustained efforts have been directed towards the improvement of its prevention, diagnosis and treatment 44–98 . There has been increasing interest in dermoscopy, as several studies have suggested improved diagnostic accuracy compared with clinical diagnosis by naked eye examination 47 .…”

Section: Dermatological Surgery and Oncologymentioning

confidence: 99%

Updates from the British Association of Dermatologists 89th Annual Meeting, 7-10 July 2009, Glasgow, U.K.

Alexandroff

Flohr

Johnston

2010

British Journal of Dermatology

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This is a synopsis of the significant research and clinical papers presented at the British Association of Dermatologists meeting held during 7-10 July 2009 in Glasgow, U.K. The conference and satellite symposia highlighted the recent biological, epidemiological and therapeutic advances in dermatology. This report is not meant as a substitute for reading the conference proceedings and related references quoted in this article.

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Tumour malignancy loss and cell differentiation are associated with induction ofgefgene in human melanoma cells

Abstract: These findings support the hypothesis that the gef gene offers a new approach to differentiation therapy in melanoma.

Cited by 12 publications

References 41 publications

Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology

Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology

Decoding Toxicity

Updates from the British Association of Dermatologists 89th Annual Meeting, 7-10 July 2009, Glasgow, U.K.

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