Tumour lysis syndrome in a patient with intravascular spread from a recurrent epithelial ovarian cancer

Abstract

Tumour lysis syndrome is a potentially life-threatening oncological emergency most commonly encountered in patients with rapidly proliferating, treatment-responsive haematological malignancies. It is rarely observed in solid tumours and, to our knowledge, this is the first time that it has been reported in a cancer with an intravascular tumour extension. In this report, we describe a case of a woman who presented with recurrent ovarian cancer and was found to have tumour invading into her vasculature. The patient subsequently developed tumour lysis syndrome after receiving chemotherapy. The case highlights the importance of considering tumour lysis syndrome prophylaxis when treating patients with intravascular involvement from a solid malignancy even if, as in this case, it is a recurrent tumour. Included is a brief review of the literature. We propose that ‘intravascular tumour invasion is recognised as an important risk factor for the development of tumour lysis syndrome.

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

“…Two cases of vulvar carcinoma were found. 50 , 51 Two cases of uterine cancer were identified with one being recurrent endometrial adenocarcinoma and the second being uterine leiomyosarcoma. 53 We decided to include uterine leiomyosarcoma in this section because of its location.…”

A Case of Spontaneous Tumor Lysis Syndrome in a Patient with Ovarian Cancer

“…Solid tumors that may spontaneously rupture typically have a rapid growth, high volume, or chemosensitivity [ 3 ]. Six cases of ovarian cancer complicated by TLS have been reported in the literature, and all were associated with chemotherapy [ 5 – 10 ]. Conversely, we report on a novel case of spontaneous TLS in a patient with ovarian cancer.…”

“…It has a mortality rate as high as 40% due to inadequate preventive treatment and delayed curative treatment [ 4 ]. There are few previous reports on TLS in patients with ovarian cancer, and all were associated with chemotherapy [ 5 – 10 ]. Herein, we are the first to report on a case of ovarian cancer with spontaneous TLS.…”

A Case of Tumor Lysis Syndrome after Docetaxel Administration for Recurrent Ovarian Cancer

“…The first case referenced additionally utilized parenteral bicarbonate and furosemide in the patient's management [8,9]. A third case report documents fatal TLS after receiving carboplatin and paclitaxel chemotherapy for recurrent ovarian cancer with documented intravascular spread [10]. To our knowledge, TLS has not been reported in the literature as a complication of the treatment of ovarian cancer with docetaxel.…”