2008
DOI: 10.1590/s0004-282x2008000600021
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Tumour-like chagasic encephalitis in AIDS patients: an atypical presentation in one of them and outcome in a small series of cases

Abstract: enCefaliTiS ChagáSiCa pSeuDoTumoral en paCienTeS Con SiDa: preSenTaCión aTípiCa en uno De elloS e hiSToria De la enfermeDaD en una pequeña Serie De CaSoS

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Cited by 12 publications
(6 citation statements)
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“…CNS infection by T. cruzi is more common than myocardial damage in HIV-immunosuppressed patients [6], [7], [15], [16]. Space-occupying lesions in the white matter of the brain are the most common clinical finding, but meningitis and meningoencephalitis may also occur [31]. CNS involvement was reported in 75%–80% of patients with concomitant T. cruzi and HIV infection between 1990 (when del Castillo et al [19] described the first case of a young man with HIV infection and a lesion in the right frontal lobe with inflammatory perivascular infiltrates and clusters of T. cruzi amastigotes) and 2007 [13], [26], [32]–[40].…”
Section: Resultsmentioning
confidence: 99%
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“…CNS infection by T. cruzi is more common than myocardial damage in HIV-immunosuppressed patients [6], [7], [15], [16]. Space-occupying lesions in the white matter of the brain are the most common clinical finding, but meningitis and meningoencephalitis may also occur [31]. CNS involvement was reported in 75%–80% of patients with concomitant T. cruzi and HIV infection between 1990 (when del Castillo et al [19] described the first case of a young man with HIV infection and a lesion in the right frontal lobe with inflammatory perivascular infiltrates and clusters of T. cruzi amastigotes) and 2007 [13], [26], [32]–[40].…”
Section: Resultsmentioning
confidence: 99%
“…Nevertheless, treatment with benznidazole or nifurtimox should be initiated as soon as any symptoms of T. cruzi infection reactivation are noted, even in the absence of an increase in parasitemia [7], [15], [31], [48]. Direct microscopic examination of blood and cerebrospinal fluid may reveal the presence of T. cruzi trypomastigotes, which usually, but not always, precedes clinical manifestations [49].…”
Section: Resultsmentioning
confidence: 99%
“…In them, a more severe clinical presentation (e.g., central nervous system involvement and severe myocarditis) is observed compared to immunocompetent patients with acute Chagas disease (Pinazo et al, 2013 ). Mass lesions in the white matter of the brain are the most frequent clinical findings, but meningitis and meningoencephalitis may also occur (Sica et al, 2008 ; Pinazo et al, 2013 ). This CNS involvement was reported in 75–80% of patients coinfected with T. cruzi and HIV, being more frequent than myocardial damage (Sartori et al, 1995 , 2007 ; Cordova et al, 2008 ).…”
Section: Discussionmentioning
confidence: 99%
“…This dual infection occurs because of the secondary reactivation of chronic (latent) T. cruzi infection triggered by immunosuppression in HIV-infected patients98. In regions where Chagas’ disease is endemic, the reactivation of this parasitic infection may be the first presentation of patients with HIV infection99100 and it can cause a high mortality rate among these coinfected patients101. HIV-related immunosuppression changes the clinical manifestations of Chagas’ disease including the central nervous system involvement102.…”
Section: Diseases Due To Tissue Parasites In Hiv/aids Patientsmentioning
confidence: 99%