Tumour-induced osteomalacia (TIO)

Tumour-Induced Osteomalacia—A Long Way to the Diagnosis Facilitated by [68Ga]Ga-DOTATATE PET/CT

“…A series of six patients diagnosed with TIO originating from one diagnostic centre has been presented here. Although the number of patients is small, it is worth mentioning that approximately 1000 cases have been reported in the medical literature so far [ 1 ], including only five single reports from Poland [ 12 , 13 , 14 , 15 , 16 , 17 ]. All patients presented in this study demonstrated similar clinical signs including severe pain, proximal muscle weakness, fractures, loss of height, and deterioration in mobility.…”

“…Moreover, the [ 68 Ga]Ga-DOTATATE PET/CT could be used as a follow-up imaging modality, as in the two presented cases, it was able to indicate local recurrence after surgery. It should be underlined that [ 68 Ga]Ga-DOTATATE PET/CT was not applied in the previously published cases from Poland; tumour localization was made by palpation [13], [ 18 F]FDG-PET/CT [14], MR, and CT [15], as well as the somatostatin receptor scintigraphy [16]. It is noteworthy that for most of the described cases, the tumours were located in the pelvic region, while data from the literature reported tumours located in the pelvis in only 10.3% of patients [18].…”

Multiple bone fractures caused by severe hypophosphatemia in the course of the mandible tumour

“…the difficulty of localising the lesion and active vitamin D and phosphate substitution [5]. In recent years, attempts to treat the syndrome with burosumab (KRN23), i.e.…”